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A Hanusch

Publications and source records attributed to A Hanusch.

5 recordsLinked to original sources
PubMed2000

Digital radiography versus conventional radiography in chest imaging: diagnostic performance of a large-area silicon flat-panel detector in a clinical CT-controlled study.

OBJECTIVE: The objective of this study was to compare the diagnostic performance of a digital large-area silicon flat-panel detector with that of a conventional screen-film system in clinical chest imaging using abnormal findings documented by CT as the reference standard. SUBJECTS AND METHODS: Eighty patients (46 men and 34 women; age range,18-91 years; mean age, 63 years) who underwent CT of the chest were examined with the new digital radiography system, which is based on a 43 x 43 cm silicon flat-panel detector, and with a conventional screen-film system, which is used routinely in clinical practice. Posteroanterior and lateral radiographs were obtained. Four radiologists analyzed the digital and conventional images separately for chest abnormalities and rated the images using a five-level scale of confidence; CT was used as the reference standard. Diagnostic value was assessed using receiver operating characteristic curves for each abnormality. RESULTS: No significant differences were found between the area under the receiver operating characteristic curve of the digital and that of the conventional radiography method for almost all investigated criteria. The only exception was mediastinal abnormalities, for which the digital method provided better results than the conventional method (p < 0.05). CONCLUSION: The diagnostic performance of the new large-area silicon flat-panel detector is equivalent or superior to that of the conventional screen-film system for clinical chest imaging and can replace conventional radiography systems. This new technology offers transmission and storage possibilities inherent to digital radiology that would facilitate daily practice and reduce the initial high costs in the long-term.

Adolescent↗
PubMed1998

[CT-guided punctures: fine-needle biopsy vs. automated co-axial cutting biopsy].

PURPOSE: Comparison between fine needle aspiration (FNAB) and automated coaxial core biopsy (ACCB) of CT-guided thoracal and abdominal biopsies. METHOD: 98 patients had CT-guided biopsies of the liver (n = 26), lung (n = 36), pancreas (n = 8), presacral space (n = 16), retroperitoneum (n = 8), groin (n = 1) and mediastinum (n = 3). In 50 patients fine needle aspiration, in 48 patients ACCB was performed. Nine physicians, two of them with advanced experience, performed the procedure. RESULTS: Histologically satisfying material was achieved in 76% of the biopsies with FNAB, in 100% with ACCB. The sensitivity within the FNAB group was 59.6%, within ACCB group 97.5%. Sensitivity for the whole group was 76.7%. In pulmonary lesions the sensitivity was increased to 100% by using the ACCB method in comparison to FNAB (58%), in liver lesions from 75% (FNAB) to 92% (ACCB). 19 of 20 false negative specimens were obtained with FNAB. The less experienced physicians had a false negative rate of 43% with FNA biopsies, but only 2.2% with ACCB. CONCLUSION: In pulmonary and abdominal lesions ACCB is a procedure with rare complications and low invasivity, which is not dependent on the performing person. ACCB has a high diagnostic accuracy and should replace FNAB.

Automation↗
PubMed1989

Sequential therapy with recombinant interferons gamma and alpha in patients with unfavorable prognosis of chronic myelocytic leukemia: clinical responsiveness to recombinant IFN-alpha correlates with the degree of receptor down-regulation.

Natural and recombinant interferons (IFNs) have already demonstrated therapeutic efficacy, including cytogenetic remissions, in patients with chronic myelocytic leukemia (CML). We investigated at the level of ligand-receptor interaction the question whether heterogeneity of receptor number or affinity might contribute to primary or secondary treatment failures in CML. We therefore analyzed IFN-gamma and IFN-alpha receptor expression and regulation during treatment with recombinant IFN-gamma and IFN-alpha in 15 patients with advanced CML. We found no difference in number or affinity of constitutively expressed IFN-gamma receptors (mean 1,100) and, on average, a 30% reduction of IFN-alpha receptors (mean 750) on peripheral blood mononuclear cells (PBMNC) of patients with chronic or accelerated CML as compared to mature granulocytes and/or bone marrow cells of healthy controls, which express on average 1,050 and 1,100 IFN-gamma and IFN-alpha receptors, respectively. While IFN-gamma receptor expression on PBMNC is not influenced upon treatment with rIFN-gamma, there is a substantial downregulation of IFN-alpha receptors in the course of rIFN-alpha therapy. Our data also show a differential pattern of receptor downregulation between patients achieving complete hematologic remission (CHR) (4 out of 12) compared with patients with partial hematologic remission (PHR) and non-responders. We conclude that differences in IFN receptor number cannot explain primary or secondary treatment failures. However, the differential ligand induced downregulation of IFN-alpha receptors in patients achieving CHR compared to those with PHR or non-responders suggest a prospective value of IFN-alpha receptor determination.

Adult↗