Biomedical subjects

A Hassanene

Publications and source records attributed to A Hassanene.

2 recordsLinked to original sources

PubMedDate not supplied

Platelet function by afibrinogenemia.

Platelet function was studied in two cases with congenital afibrinogenemia. In these two cases there was no aggregation by ADP, while, there was increased calcium-induced platelet aggregation and decreased platelet adhesiveness to glass. Platelet aggregation was corrected in vitro, by addition of fibrinogen. It can be concluded from the above findings that the fibrinogen is an important factor for platelet aggregation by ADP and for platelet adhesion to glass surfaces, while platelet aggregation by thrombin does not need fibrinogen. The increased calcium-induced aggregation can be explained by postulating that thrombin finds no substrate to act upon except the platelets.

Afibrinogenemia↗

PubMedDate not supplied

Studies on platelet function in cases of hemophiliac Egyptian children.

Eleven cases of hemophilia were studied for detection of any change in the platelet function. The results showed hyperfunction in 5 cases, normal function in 4, and hypofunction in the remaining two. The hyperfunction of the platelets was shown in the case with acute hemorrhage and it might be a compensation mechanism. The normal function was shown in cases during the quiescent phase. The hypofunction of the platelets was associated with the presence of AHg inhibitor and platelet antibody. Normal function returned after Cortisone administration. It may be postulated that the inhibitor of factor VIII and the platelet antibody are one and the same thing.

Adolescent↗