A Heidorn | PubMed Health

PubMed1987

Sequence of affective polarity and lithium response: preliminary report on Munich sample.

As an alternative to the bipolar I/II distinction, a subtyping of bipolar affective disorders according to the sequence of polarity (mania or depression) has been proposed. In a study of 93 patients with bipolar affective and bipolar schizoaffective disorders we tested the stability of a subtyping using the sequence of polarity. Furthermore we investigated its relationship to bipolar I/II subtypes and to response to stabilizing therapy with lithium. In the individual patient the first sequence of polarity significantly predicted the same sequence of polarity of further manifestations. However, only half of the patients could be classified as either MDI (mania-depression-interval) or DMI (depression-mania-interval). Subtyping according to the sequence of polarity was not significantly related to the bipolar I/II subgroups. MDI patients showed a significantly better response to stabilizing therapy with lithium than DMI patients. Our findings lend support to the notion that the polarity sequence is of clinical relevance. The observed association between polarity sequence and effectiveness of lithium prophylaxis could be linked to direct consequences of a MDI or DMI sequence (e.g.: different treatment approaches). On the other hand, a difference in polarity sequence might be the clinical expression of a difference in the underlying mechanisms of dysregulation, which in turn might be more or less prone to respond to lithium therapy.

Bipolar Disorder↗

PubMedDate not supplied

Third time around for hyperbaric oxygen therapy.

Hyperbaric medicine, which was called compressed air therapy prior to 1956, began in the 1830s in England and France. After initial enthusiasm for this treatment, interest began to wane because of a lack of documentation of benefit. The medical community became skeptical, and use of the modality diminished. In the 1900s there was a resurgence of interest, but again, due to a lack of data and because conferences on the therapy were devoted more to the research aspects of complications than to clinical uses, less and less attention was given to potential applications. During the past 15 to 20 years, interest in hyperbaric medicine has reemerged. However, despite the facts that its uses are now well documented and that eminent professionals are involved in hyperbaric research and application, the field has never quite recovered from the equivocal role it once played.

Humans↗