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Biomedical subjects

A Herrlinger

Publications and source records attributed to A Herrlinger.

6 recordsLinked to original sources
PubMed1992

[The significance of tumor diameter in renal cell carcinoma].

The data of 740 patients who were operated on for renal cell carcinoma between 1975 and 1986 have been evaluated. We studied the relation between tumour size and other factors influencing the prognosis, such as tumour stage, infiltration of renal veins and incidence of metastases at the time of nephrectomy, and between tumour grading and postoperative survival. Sixty-six patients with small tumours were divided in groups according to tumour size: less than 20 mm, less than 25 mm, less than 30 mm, less than 40 mm. All 740 patients were separated into groups according to tumour size: less than 4 cm, 4-6 cm, 6-8 cm, 8-10 cm and greater than 10 cm. Stage pT1 carcinomas (less than 25 mm) occurred in 1.4% of patients and tumours exceeding 10 cm in size in 30%. The prognosis with regard to survival becomes worse the greater the diameter of the tumour: the incidence of renal vein involvement, metastases and higher grades of malignancy increases. Postoperative survival decreases in relation to the increase in tumour size. Carcinomas less than 30 mm in diameter were found to have distant metastases in only 1 case, while invasion of renal veins occurred in 2 cases. In tumours up to 3 cm in diameter, a kidney-preserving tumour resection seems possible without limiting the radicalness of the surgery.

Carcinoma, Renal Cell↗
PubMed1991

What are the benefits of extended dissection of the regional renal lymph nodes in the therapy of renal cell carcinoma.

In a prospective study of 511 patients we compared the data of 320 who underwent systematically extended dissection of the regional lymph nodes with data of 191 who underwent only facultative dissection of the lymph nodes, which means that no lymph nodes had been removed or only a few were taken for staging purposes. Only patients without distant metastases and who were less than 72 years old were included. All patients were treated with a transabdominal approach. The incidence of positive nodes in the patients with systematically extended lymphadenectomy was 17.5% and for patients with facultative lymphadenectomy it was 10%. Survival rates of patients with facultative lymphadenectomy were 58% after 5 years and 40.9% after 10 years, compared to 66% and 56.1%, respectively, for patients with systematically extended lymphadenectomy (p less than 0.01). Patients with stage pT1-2 (Robson stage I) and pT3aN0M0 (Robson stage II) tumor obviously had the highest benefits with extended lymphadenectomy. Operative mortality was less than 1% after systematically extended lymphadenectomy and 3.8% after facultative lymphadenectomy. We conclude from our data that the systematic and extended lymphadenectomy improves the prognosis of patients with renal cell carcinoma without any additional operative risks.

Carcinoma, Renal Cell↗
PubMed1979

[Recurrence of inguinal, undescended, testicle (author's transl)].

An analysis of 94 patients from 1970 to 1977 demonstrates the problems of recurrence of the inguinal undescended testis. In more than 2/3 of the patients operative deficiencies were considered as the cause. The technique of secondary corrective surgery is described. The special difficulties with short internal spermatic vessels are outlined. In 90% of the patients a good anatomical result was obtained but no data are available concerning later functional results.

Cryptorchidism↗
PubMed1978

[Transvenous perfusion, a new simple and effective technique of regional renal hypothermia. An experimental study (author's transl)].

In an experimental study, involving ten dogs, the feasibility of transvenous perfusion cooling of the kidney is proven. The theoretical basis of this new method of regional renal hypothermia is presented. The technique is easy to perform and requires cannulation of the renal vein. The perfusate leaves the kidney either via the capsular veins which were divided during renal exposure or through the proposed nephrotomy. Renal vein thrombosis or venous disruption have not been observed. The only complication encountered in one instance was hemorrhage from the puncture site of the renal vein.

Animals↗
PubMed1978

[The pharmacological treatment of the incontinent neurogenic bladder (author's transl)].

An attempt is made to describe the action of sympathic, parasympathic and somatic innervation of the urinary bladder by means of a receptor model and to present the theoretical basis of a successful treatment of the neurogenic bladder. Radiographic and urodynamic examination of 15 children revealed that ephedrine was successful in improving or curing urinary incontinence in 12 cases with congenital or required neurogenic bladder. The requirements and limitations of a successful sympathomimetic treatment of the neurogenic incontinence are presented.

Adolescent↗