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Biomedical subjects

A Hessel

Publications and source records attributed to A Hessel.

At least 19 recordsLinked to original sources
PubMed2005

[Prevalence of urinary incontinence in the German population].

The purpose of this study was to determine the frequency of incontinence in men and women in different age groups. In a representative survey, 883 men and 1,182 women with a mean age of 50 years (18-92 years) were studied based on standardized questionnaires on physical and psychological complaints, and quality of life. Participants suffering from involuntary loss of urine were considered "incontinent". The frequency of incontinence strongly increased with age, from 6.9% among the 18-40 year old population to 9.5% among the 41-60 year olds and 23% over the age of 60 years. Women complained more frequently of incontinence (15%) than men (9.5%; total of 12.6% in the population). The majority of the participants with incontinence also suffered from urinary urge, multiple disorders of digestion, pelvic pain and sexual dysfunction. There was also a strong increase in exhaustion, gastric pain, joint pain and cardiac complaints. The younger participants were more strongly affected by incontinence. When patients complain of incontinence, strong impairments in physical and psychological well-being, and quality of life are to be expected.

Adaptation, Psychological↗
PubMed2003

[Somatoform complaints in elderly of Germany].

The aim of this paper is to report on the prevalence of somatoform disorders in older age. A total of 630 representatively selected persons older than 60 years were asked to complete the questionnaire SOMS 2 (Screening for somatoform disorders, Rief et al., 1997). The results show that somatoform pain is very common in old age. Of the people, 71.8% report at least one symptom, 50.5% on at least four symptoms and 23.4% suffer from at least eight symptoms. The frequency of somatoform symptoms is much higher in people over 60 years old than in persons who are younger than 60 years old. Pain is very often localized in several body regions. In contrast to findings from younger age groups, older women do not report more somatoform pain than older men. When looking at the differences between "young olds" and "old olds" somatoform pain increases with increasing age. The high frequency of somatoform pain in older people is in clear contrast to the low prevalences of somatoform disorders defined according to DSM-IV or ICD-10 (0%-0.3%). The results show that the real prevalence of somatoform disorders is extremely underestimated because of the restrictive criteria of the diagnosis systems.

Age Factors↗
PubMed2001

[Psychiatric problems in the elderly--standardization of the Symptom Check List SCL-90-R in patients over 60 years of age].

In the following article, data of the symptom checklist SCL-90-R (Derogatis 1986) for elderly people are introduced, including an estimation of the controlling factors on psychological complaints in old age. The representative sample is based on 394 persons aged 61 to 96; their psychological complaints have been studied with respect to SCL-90-R. Evidently elderly people did not state an increasing load on psychological complaints, but a different structure of psychological symptoms. Therefore with increasing age the scales "Somatization", "Obsessive-compulsive" and "Phobic anxiety" increase, while "Interpersonal sensitivity", "Anger--hostility" and "Paranoid ideation" are decreasing. Within that frame, elderly females report increasing symptomatic load compared to elderly males. Furthermore, aspects of social support and health-related attitudes were found to be important predictors of psychological complaints in old age.

Aged↗
PubMed2000

[Utilization of medical services and medication intake of patients over 60 in Germany--health related, social structure related, socio-demographic and subjective factors].

In a community sample of 394 elderly aged 61 years and older from East and West Germany, diseases, contacts with general practitioners and specialists, the use of medicine, attitudes regarding health and illness, the subjective health, psychic problems, social support, social integration, social burden, and socio-demographic variables were assessed. Based on these data the determinants for the contact of physicians and the use of medicine were analyzed. The results confirmed the frequency of multimorbidity in the elderly; on average we found three different diseases at the same time for each person. In nearly 10% of the sample we found seven diagnoses existing at the same time. 88% had contact with a general practitioner at least once a year, 97% had contact either with a general practitioner or with a specialist once a year. 55.8% took at least one medicine each day. The number of diseases existing at the same time was the most determining variable for the contact of physicians and the use of medicine. Furthermore, the elderly had more contact with physicians and took more medicine if they thought they were susceptible to diseases in a high degree, and if they rated their own health as poor. Fewer contacts with physicians and a lower use of medicine were found in those elderly that rated health behavior as little useful, that had low control beliefs regarding their own health, and that experienced only a low degree of health-related limitations in their everyday life. Furthermore, we found a higher use of medicine if there was little social support. There were no significant age-related or sex-related differences regarding the contact of practitioners or the use of medicine.

Aged↗
PubMed2000

[Illness-coping in a population-based representative sample. Situational, sociodemographic and social influences].

In spite of the considerable volume of current coping research there is a noticeable lack of studies based on large representative samples. In this study a sample of 2179 subjects of 16 to 96 years of age that was representative of the entire population of Germany, was asked as to how they now cope, how they have coped in the past or how they would cope with: 1. an existing illness, 2. a past illness and 3. an imagined (non-existent) illness. The instrument used was the questionnaire version of the "Berner Bewältigungsformen" (BEFO), a coping questionnaire with 28 systematically derived coping dimensions that are defined independently of the usual empirical-topographical dimensions (behavioural, cognitive and emotional) of the type of illness. The enquiry was concerned with the influence of varying situational (proximity of illness, subjective evaluation of personal health, psychological symptoms), socio-demographic (age, gender) and social (social support) variables on the choice of coping mechanisms. The results showed that each of these factors influences the repertoire of coping mechanisms to varying degrees. This systematic variability in a representative sample should be taken into account in any evaluation of coping with illness in clinical sub-groups.

Adaptation, Psychological↗
PubMed1999

Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells.

Gene expression patterns can provide vital clues to the pathogenesis of neoplastic diseases. We investigated the expression of 950 genes in Hodgkin's disease (HD) by analyzing differential mRNA expression using microarrays. In two independent microarray experiments, the HD-derived cell lines L428 and KMH2 were compared with an Epstein-Barr virus (EBV)-immortalized lymphoblastoid B cell line, LCL-GK. Interleukin (IL)-13 and IL-5 were found to be highly expressed in the HD-derived cell lines. Examination of IL-13 and IL-5 expression by Northern blot analysis and enzyme-linked immunosorbent assay confirmed these results and revealed the expression of IL-13 in a third HD-derived cell line, HDLM2. Control LCL and EBV-negative non-Hodgkin lymphoma-derived cell lines did not express IL-13. In situ hybridization of lymph node tissue from HD patients showed that elevated levels of IL-13 were specifically expressed by Hodgkin/Reed-Sternberg (H/RS) tumor cells. Treatment of a HD-derived cell line with a neutralizing antibody to IL-13 resulted in a dose-dependent inhibition of H/RS cell proliferation. These data suggest that H/RS cells produce IL-13 and that IL-13 plays an important role in the stimulation of H/RS cell growth, possibly by an autocrine mechanism. Modulation of the IL-13 signaling pathway may be a logical objective for future therapeutic strategies.

Cell Division↗
PubMed1999

Chlamydia infections and heart disease linked through antigenic mimicry.

Chlamydia infections are epidemiologically linked to human heart disease. A peptide from the murine heart muscle-specific alpha myosin heavy chain that has sequence homology to the 60-kilodalton cysteine-rich outer membrane proteins of Chlamydia pneumoniae, C. psittaci, and C. trachomatis was shown to induce autoimmune inflammatory heart disease in mice. Injection of the homologous Chlamydia peptides into mice also induced perivascular inflammation, fibrotic changes, and blood vessel occlusion in the heart, as well as triggering T and B cell reactivity to the homologous endogenous heart muscle-specific peptide. Chlamydia DNA functioned as an adjuvant in the triggering of peptide-induced inflammatory heart disease. Infection with C. trachomatis led to the production of autoantibodies to heart muscle-specific epitopes. Thus, Chlamydia-mediated heart disease is induced by antigenic mimicry of a heart muscle-specific protein.

Adoptive Transfer↗
PubMed1999

Identification of a cross-reactive self ligand in virus-mediated autoimmunity.

Molecular mimicry has been considered to be one of the potential mechanisms underlying the induction of autoimmune diseases. Using a TCR-transgenic model specific for lymphocytic choriomeningitis virus (LCMV) we have examined the potential for cross-reactive recognition of tissue-restricted self peptides. Several peptides were identified that were able to cross-react with the TCR-transgenic virus-specific T cells in vitro. One peptide was derived from dopamine beta-mono-oxygenase, an enzyme expressed in the adrenal medulla. Interestingly, after activation of the transgenic T cells with LCMV glycoprotein peptides or viruses, infiltration of the adrenal medulla was detected in conjunction with alterations in dopamine metabolism. However, complete destruction of the adrenal medulla was not observed. This suggests that molecular mimicry may be sufficient for self recognition and infiltration, but other factors clearly contribute to chronic autoimmune disease.

Allergens↗
PubMed1999

[Coping with disease in the elderly - the effect of perceived control, subjective morbidity, social support and socio-demographic variables].

In a community sample of 165 elderly aged 61 to 96 years (mean 69.65 years) from East and West Germany, present diseases, subjective health, impairments, health-related control-beliefs, social support (F-SOZU; Sommer & Fydrich, 1989), and health related coping-styles ("Bern Coping Styles Questionnaire" BEFO; Heim et al., 1991) were assessed. By means of a stepwise multiple regression analysis, the differential impact of control beliefs, subjective morbidity, subjective health, social support, social integration, social burden, and socio-demographic variables (age, sex, educational level) was analyzed. Elderly with little health related impairments, emotional support, and a relatively high educational level tried to cope with diseases by lowering the affective burden by cognitive and behavioral strategies. A growing number of diseases, a high level of practical help by others, but also a high degree of social burden were the best predictors for a health related coping strategy that is characterized by avoiding the preoccupation with the disease and by searching for emotional support. A health related coping style that is characterized by lamentation, brooding, and resignation was predicted best by poor subjective health, a high degree of social burden, and a low educational level.

Adaptation, Psychological↗
PubMed1999

Assessment of the functional role of accessory pudendal arteries in erection by transrectal color Doppler ultrasound.

PURPOSE: Anatomical studies have demonstrated accessory pudendal arteries originating from supralevator vessels in about two-thirds of men. Injury to accessory pudendal arteries derived from inferior vesical and obturator arteries has been reported to be responsible for vasculogenic impotence after nerve sparing radical prostatectomy. We performed transrectal and perineal color Doppler ultrasound in patients before radical pelvic surgery to identify accessory pudendal arteries and assess their functional role during erection. MATERIALS AND METHODS: A total of 12 patients with a mean age of 60 years were examined before radical prostatectomy (10) or cystoprostatectomy (2). Transrectal and perineal color Doppler flow imaging and spectral waveform analysis were performed. Peak systolic velocity, end diastolic velocity, resistive index and arterial diameter were measured before and during pharmacologically induced erection. Transrectal color Doppler ultrasound data were compared with intraoperative findings. RESULTS: Transrectal color Doppler ultrasound visualized accessory pudendal arteries derived from supralevator arteries in 9, and prostatic and seminal vesicle arteries in all patients. Perineal color Doppler ultrasound visualized internal pudendal arteries in all patients. After intracavernosal injection of papaverine accessory and internal pudendal arteries displayed similar significant hemodynamic changes. Diameter as well as peak systolic and end diastolic velocities increased, and resistive index decreased. Prostatic and seminal vesicle arteries showed no significant change. Presence and location of accessory pudendal arteries demonstrated by transrectal color Doppler ultrasound were confirmed by intraoperative findings. CONCLUSIONS: During pharmacologically induced erection hemodynamic changes in accessory and internal pudendal arteries are similar to those described in cavernous arteries, thus demonstrating the functional role of accessory pudendal arteries in penile erection. Color Doppler ultrasound appears to be reliable to examine internal and accessory pudendal arteries based on morphological and functional criteria.

Aged↗
PubMed1999

Calciphylaxis associated with metastatic breast carcinoma.

Calciphylaxis is a rare disorder associated with calcification of small- and medium-sized blood vessels, and progressive skin necrosis usually seen in the setting of end-stage renal disease (ESRD) and secondary hyperparathyroidism. It has also been observed in primary hyperparathyroidism, hypercalcemia of malignancy (extensive bony metastasis of breast cancer), and an isolated case reported with end-stage liver disease. We report an unusual case of calciphylaxis associated with metastatic breast carcinoma in the absence of renal or parathyroid disease. Calciphylaxis has generally been associated with end-stage renal disease and hyperparathyroidism. One previous case report described calciphylaxis occurring in a patient with metastatic adenocarcinoma of the breast and hypercalcemia. Our case represents the second reported case of calciphylaxis associated with osteolytic, metastatic breast cancer. Although ESRD with secondary hyperparathyroidism is the most common presentation of calciphylaxis, this case demonstrates that other conditions that alter normal calcium metabolism must be considered in the differential diagnosis.

Bone Neoplasms↗
PubMed1999

[Subjective assessment of self health and subjective morbidity in Germany. Results of a representative demographic survey].

This study presents selected results from the poll of a representative cross-section of the German population during the Spring of 1996 was subjective data on health and illness investigated, inter alia. The majority of the questioned subjects stated good health with low impairment of their general condition by their general conditions by their health. Compared with data from 1975, people have the impression that their health is in a better state, but, on the other hand, more significantly inparied by their health. East Germans claim a somewhat lower state of health and more impairment than West Germans; the same results were found for women in comparison with men and elderly persons compared with younger subjects. There is no difference between East and West Germans with respect the frequency of disease, but there were more illnesses with a clear morphological correlation reported by East-Germans. West Germans report more functional infirmities or troubles. One of the most striking results was the high frequency of cardiovascular disorders in East Germany. The influence of social support and social status on the subjective assessment of one's own health and subjective morbidity is of only low importance.

Adolescent↗
PubMed1999

[The situation of young people in Germany--results of a representative population survey].

Youth and adolescence is one of great periods of upheaval during a human lifetime. Separation from parents and forming a stable individual identity are major themes. The present study outlines results relevant to this issue taken from three representative surveys of German population. The average results for various psycho-social parameters applying to young people in the country as a whole reflect a well-integrated, relatively contented and stable generation. Differentiating these results according to place of residence (East vs. West Germany) demonstrates, firstly, that psycho-social gap between East and West is closing faster among the younger generation than among the older sections of the population and, secondly, that East German youth is particularly burdened by special problems. The diminishing role of family as a stabilizing "counterpole" in the face of increasing objective difficulties and the possible consequences of this trend for young people is discussed in connection with the findings.

Adolescent↗
PubMed1998

Molecular cloning of multiple isoforms of synaptojanin 2 and assignment of the gene to mouse chromosome 17A2-3.1.

Synaptojanin 2 is an inositol polyphosphate 5'-phosphatase that appears to be regulated by alternative splicing. By screening mouse cDNA libraries derived from either mouse day 16 embryo or adult liver, we have identified additional synaptojanin 2 cDNAs that represent six new isoforms of the protein. This finding, together with other reports, indicates the presence of eight isoforms of synaptojanin 2. Sequence analysis of our cDNA clones suggests that there are at least two putative initiation sites and at least six different sequences coding for the carboxyl-terminus of the molecule. In addition, we have mapped synaptojanin 2 to mouse chromosome 17 band A2-3.1 by fluorescence in situ hybridization.

Alternative Splicing↗
PubMed1997

5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II.

We have investigated the role of the RNA Polymerase II (Pol II) carboxy-terminal domain (CTD) in mRNA 5' capping. Transcripts made in vivo by Pol II with a truncated CTD had a lower proportion of capped 5' ends than those made by Pol II with a full-length CTD. In addition, the enzymes responsible for cap synthesis, RNA guanylyltransferase, and RNA (guanine-7)-methyltransferase bound directly to the phosphorylated, but not to the nonphosphorylated, form of the CTD in vitro. These results suggest that: (1) Pol II-specific capping of nascent transcripts in vivo is enhanced by recruitment of the capping enzymes to the CTD and (2) capping is co-ordinated with CTD phosphorylation.

Amino Acid Sequence↗
PubMed1996

A new family of regulators of G-protein-coupled receptors?

Organisms as diverse as fungi and humans use G-protein-coupled receptors to control signal transduction pathways responsive to various hormones, neuroregulatory molecules and other sensory stimuli. Continual stimulation of these receptors often leads to their desensitization, which is mediated in part by the consecutive actions of two families of proteins--the G-protein-coupled receptor kinases, which phosphorylate the agonist-occupied receptors, and the arrestin proteins, which subsequently bind to the receptors. We now present evidence that a group of proteins--the G0S8/Sst2p family--may be a third class of receptor-desensitizing factors.

Amino Acid Sequence↗
PubMed1995

Genetic map of Salmonella typhimurium, edition VIII.

We present edition VIII of the genetic map of Salmonella typhimurium LT2. We list a total of 1,159 genes, 1,080 of which have been located on the circular chromosome and 29 of which are on pSLT, the 90-kb plasmid usually found in LT2 lines. The remaining 50 genes are not yet mapped. The coordinate system used in this edition is neither minutes of transfer time in conjugation crosses nor units representing "phage lengths" of DNA of the transducing phage P22, as used in earlier editions, but centisomes and kilobases based on physical analysis of the lengths of DNA segments between genes. Some of these lengths have been determined by digestion of DNA by rare-cutting endonucleases and separation of fragments by pulsed-field gel electrophoresis. Other lengths have been determined by analysis of DNA sequences in GenBank. We have constructed StySeq1, which incorporates all Salmonella DNA sequence data known to us. StySeq1 comprises over 548 kb of nonredundant chromosomal genomic sequences, representing 11.4% of the chromosome, which is estimated to be just over 4,800 kb in length. Most of these sequences were assigned locations on the chromosome, in some cases by analogy with mapped Escherichia coli sequences.

Chromosome Mapping↗