PubMed Health⌕ Search

Biomedical subjects

A Heyndrickx

Publications and source records attributed to A Heyndrickx.

At least 37 records · Page 2Linked to original sources
PubMed1981

Clinical experience with prolonged combined hemoperfusion-hemodialysis treatment of severe poisoning.

Fifteen patients with severe drug intoxication have been treated by a procedure combining hemoperfusion (HP, cellulose-coated activated charcoal, Adsorba C300, Gambro, Sweden) and hemodialysis (HD). The combined HP-HD treatment resulted in a clearance for amobarbital of 121 +/- 10 ml per min (mean +/-SEM), butobarbital 142 +/- 4 ml per min, carbromal 121 +/- 6 ml per min, hexobarbital 181 +/- 13 ml per min, meprobamate 145 +/- 9 ml per min, methaqualone 137 +/- 5 ml per min, phenobarbital 138 +/- 4 ml per min, and secobarbital 125 +/- 4 ml per min. There was no decrease in drug extraction even after 30 hours of treatment. Duration of treatment (6 to 33 hours) was determined by the clinical state of the patient. Prolonged HP-HD seemed to ben an efficient and sage procedure. Of 15 patients treated, 14 regained consciousness and 12 survived. The platelet count decreased, necessitating cessation of treatment in two cases. There was extraction of oxygen by the charcoal column, without influence on patient Po2. Glucose, urea, creatinine, uric acid, phosphate, and triglycerides were removed by adsorption on charcoal and/or dialysis.

Diuresis↗
PubMed1980

GLC-mass spectral determination of mescaline in plasma of rabbits after intravenous injection.

A GLC-mass spectral analysis with a deuterated internal standard was developed to measure plasma mescaline concentrations after intravenous administration to rabbits. The drug and the internal standard were extracted with benzene, derivatized with trifluoroacetic acid anhydride, and chromatographed on 2.5% QF-1 with mass fragmentographic detection. The detection limit is 5 ng/ml of plasma. The relative standard deviation was approximately 5%. The main advantage of this method is that it combines the specificity of the GLC retention time and mass spectral fragmentation pattern with the sensitivity of the mass fragmentographic detection.

Animals↗
PubMed1979

Selection of a high performance liquid chromatographic cleanup procedure for the determination of organochlorine pesticides in fatty biological extracts.

Two different high performance liquid chromatographic cleanup methods, absorption chromatography and nonaqueous reversed-phase chromatography, were investigated and their respective adventages discussed. The first was performed on 5 cm silica and alumina columsn, while for the latter a 5 cm octadecylilica column was used. Optimum mobile phase moderator concentrations were selected in order to achieve complete separation between the most retained organochlorine pesticide (endosulfan sulfate) and lipids on absorption columns. Separation efficiency was controlled by monitoring the eluate at 205 nm. The specific application fields of the described approaches were indicated and their possibility to preclude extracts from up to mg of lipid substances proved.

Chromatography, High Pressure Liquid↗
PubMed1979

EC-GLC determination of the herbicidal monohalogenated phenoxyalkyl acid mecoprop in tissues, urine and plasma after derivatization with pentafluorobenzylbromide.

An EC-GLC method for the determination of the systemic herbicide methylchlorophenoxypropionic acid (meco prop), a monohalogenated phenoxyalkyl acid, in 0.5 gram of rabbit tissues and in one ml human urine and plasma, is presented. Monohalogenated chlorophenoxyalkyl acids can reach a high sensitivity for electron-capture detection as pentafluorbenzylester derivatives; so their minimum detectable amount is about 5 pg. A test-tube micro-extraction method for MCPP fromurine, plasma and homogenized tissues with benzene, after acidification with 2 N HC1, the derivatization the residue, and the column clean-up over silicagel, are described in detail. Results of recovery studies with variation-coefficient determination are given by analysis of spiked tissues liver and brain, urine and plasma using p-chlorophenoxy-isobutyric acid (CPIB) as the internal standard. With this method other chlorophynoxyalkyl acid herbicides also can be determined in biological post-mortem material

2-Methyl-4-chlorophenoxyacetic Acid↗
PubMed1977

Toxicological analysis in a case of endosulfan suicide.

Stomach, small intestine contents, blood, liver, kidney and urine of a 28-years old man, were analyzed for residues of Endosulfan (6, 7, 8, 9, 10, 10-hexachloro-1, 5, 5a, 6, 9, 9a-hexahydro-6, 9-methano-2, 4, 3-benzo(e)dioxathiepin 3-oxide). The analysis results showed the presence of high concentrations of the two endosulfan isomers in all samples. Since also alcohol was present in all the tissues analyzed, it was concluded that the victim died of a combined endosulfan-alcohol poisoning. No other drugs were found.

Adult↗
PubMed1975

The excretion in urine of four insecticidal carbamates and their phenolic metabolites after oral administration to rats.

4 insecticidal carbamates: 3-methyl, 5-isopropylphenyl N-methyl-carbamate (Promecarb), 4-methylthio, 3,5 dimethylphenyl N-methylcarbamate (Mesurol), 4-dimethyl-amino, 3,5 dimethylphenyl N-methylcarbamate (Zectran), and 4-benzothienyl N-methyl-carbamate (Mobam) were orally administered to male Wistar rats. The excretion of the unchanged products was followed in 24 hrs urine collections. The corresponding phenols of the different carbamates could be identified as metabolites by gas-chromatography-mass spectrometyr. These metabolites were quantified afterward by gas-liquid chromatography. In all cases only minor quantities of unchanged products and metabolites were excreted in the urine over the 48 hrs after administration.

Administration, Oral↗