PubMed Health⌕ Search

Biomedical subjects

A Horvàth

Publications and source records attributed to A Horvàth.

5 recordsLinked to original sources

Preoperative risk assessment in elective general surgery.

Despite improved surgical techniques there is still a risk of mortality in elective general surgery. In a prospective study preoperative data from 3250 patients were collected and compared with postoperative systemic complications, using univariate chi 2 analysis. Highly significant (P < 0.00001) variables were subjected to stepwise logistic regression analysis. The severity of operative procedure, higher American Society of Anesthesiologists (ASA) grade, symptoms of respiratory disease and malignancy were found to be significant risk factors predicting postoperative morbidity (P < 0.05). Using these four variables, a simple preoperative risk scoring system has been defined. Class A (up to 5 points) was defined as a low-risk group (systemic complication rate 5.0 per cent), class B (5-7 points) was intermediate risk (systemic complication rate 17.9 per cent) and class C (8-10 points) was high risk (systemic complication rate 33.3 per cent). Patients at high risk for perioperative and postoperative complications are more likely to be identified by this analysis than by using the ASA classification alone.

Elective Surgical Procedures↗

[Risk assessment before elective visceral surgery interventions].

AIM OF THE STUDY: Since 1988 all our patients undergoing elective general surgery entered a prospective study, with the aim of identifying risk factors, responsible for a fatal postoperative outcome. METHODS: From 1988-1992 a total of 3250 patients (mean age 52.0 years [SD +/- 16.8]), 1750 male and 1500 female have been registered. RESULTS: General complications occurred in 10.4% of patients and local complications have been registered in 10.8% of cases. 29 patients (0,89%) died within 30 days following the operative procedure. The operation per se, the ASA-classification, a history of respiratory disease and an operation for a malignant disease could be identified as risk factors for general postoperative complications. CONCLUSIONS: The study design allows us to determine risk factors in elective general surgery. These risk factors can easy be used in clinical practice to evaluate the operative risk of a planned operative procedure.

Adult↗

A simple method for detecting HIV antibodies hidden in circulating immune complexes.

A method previously used for studying the specificity of antibody components of circulating immune complexes in different diseases has been applied to analyse circulating immune complexes in HIV-infected patients. Antibodies against HIV antigens hidden in circulating immune complexes were studied in 14 sera from 13 patients with asymptomatic HIV infection (group 1) and in 11 sera from seven patients with HIV symptoms (group 2). HIV antigen-coated wells from the Vironostika kit as well as core and envelope antigen-coated beads from the Abbott confirmatory kit were used as solid-phase antigen. Using the Vironostika plates, HIV antibodies were demonstrated in circulating immune complexes in three and five sera in groups 1 and 2, respectively. Anti-core antibodies hidden in circulating immune complexes were present in three out of eight and two out of nine sera, respectively, in groups 1 and 2, whereas anti-envelope antibodies were present in circulating immune complexes in one out of eight and six out of nine sera in the same groups. These findings demonstrate that not only core-anti-core but also envelope-anti-envelope immune complexes are present in the sera of HIV infected patients.

Acquired Immunodeficiency Syndrome↗