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Biomedical subjects

A Hosková

Publications and source records attributed to A Hosková.

At least 19 recordsLinked to original sources
PubMed1980

Severe lactose intolerance with lactosuria and vomiting.

An infant with lactose intolerance is described. A breast-fed infant developed vomiting at 3 weeks, and became dehydrated. Lactosuria, aminoaciduria, and liver damage were preesent. A milk-free diet led to rapid recovery. At 6 months a normal diet was well tolerated.

Humans↗
PubMed1977

Haemorrhagic diathesis as a possible early sign of hereditary fructose intolerance.

An infant girl three weeks of age with the leading symptom of skin haemorrhages is presented. On further investigation, the signs of severe hepatic damage with hypofibrinogenaemia and prothrombin complex impairment, and renal tubular dysfunction were disclosed. All these pathological symptoms, which were reversed on fructose free diet, were caused by hereditary fructose intolerance.

Afibrinogenemia↗
PubMed1976

Serum gamma-glutamyl transpeptidase activity and urinary D-glucaric acid excretion in newborns in the first week of life. Effects of phenobarbital and nicethamide combination.

High serum gamma-glutamyl transpeptidase activity was found in cord blood of newborn boys. This activity decreased to lower values on the 4th and 7th days. In newborns treated for 3 days following the birth with a combination of phenobarbital and nicethamide an increase of gamma-glutamyl transpeptidase activity occurred from the 4th to the 7th days. The 7th day levels were significantly higher when compared with the controls. Simultaneous determination of urinary glucaric acid excretion confirmed the induction of hepatic microsomal enzymes in glucuronic acid pathway. This could also be demonstrated by a pronounced decrease of serum bilirubin levels in groups receiving the enzyme inducers whether phenobarbital was administered intramuscularly or orally as sodium salt solution.

Bilirubin↗
PubMed1975

Glucaric acid excretion as index of hepatic glucuronidation in neonates after phenobarbital treatment.

The urinary excretion of glucaric and glucuronic acid was investigated in neonates receiving phenobarbital intramuscularly or orally. Whereas there was no significant difference from the control-subjects in glucuronic acid elimination, the increase in glucaric acid excretion was significantly higher in the intramuscularly treated neonates. Infants with orally administered phenobarbital showed only insignificantly greater glucaric acid elimination. The decrease of serum bilirubin levels was more pronounced in the intramuscularly treated than in the orally treated group. The determination of glucaric acid may be an important reflection of hepatic microsomal induction of the enzymes of the glucuronic acid pathway.

Adipates↗