Biomedical subjects
A Hossenbocus
Publications and source records attributed to A Hossenbocus.
Macromolecular aspartate aminotransferase.
Macroenzymes are serum enzymes that have a greater molecular mass than the corresponding enzyme normally found in serum (Klonoff. West J Med 1980; 133: 392-407). Serum AST (aspartate aminotransferase) has rarely been reported to complex with immunoglobulins, resulting in an elevation in serum AST activity. Physicians should be aware of this condition so that patients are not subjected to invasive and costly procedures unnecessarily (Litin et al. Mayo Clin Proc 1987; 62: 681-687). We report on such a patient with a raised AST due to macroenzyme formation.
Rhabdomyolysis with renal dysfunction in a hypothermic man.
We describe a case of rhabdomyolysis with renal dysfunction in a 41-year-old previously healthy man with hypothermia. We believe this to be the first case of rhabdomyolysis and hypothermia so far described in the UK.
Death following dystonic reaction to oral metclopramide.
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Crohn's disease in a husband and wife.
The case-histories of a husband and wife in whom Crohn's disease developed after more than 30 years of marriage are described.
Letter: Steatorrhoea complicating therapy with mefenamic acid.
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Potential difference across the normal and the abnormal gastric mucosa in man.
The mucosal potential difference in the body of the stomach was measured in 18 patients with gastric ulcers, five with gastritis, and three with pernicious anaemia. The results were compared with those of 12 normal volunteers. Significantly lower than normal levels were found in the groups of patients with gastric ulcers and gastritis. The patients with pernicious anaemia had even lower potential differences. In an additional 25 subjects, measurements were made in the duodenal bulb and at five sites in the stomach under direct vision at endoscopy. Biopsies were taken from each site for histology. Subjects with gastritis at the high lesser curve had a significantly lower potential difference at that site than those without gastritis. In the latter group, the potential difference at the high lesser curve was as low as in the antrum, and invariably lower than at the high greater curve.
Proceedings: Measurement of gastric mucosal potential difference at endoscopy.
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Proceedings: The effects of aspirin, carbenoxolone, and gefarnate on the gastric mucosal potential difference in man.
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Trichobezoar, gastric polyposis, protein-losing gastroenteropathy and steatorrhoea.
A mentally subnormal patient presenting with oedema was found at gastroscopy to have a large trichobezoar and multiple gastric polyps. The serum concentrations of albumin and IgG were low in the absence of proteinuria, and the gastrointestinal clearance of radiochromium after the intravenous administration of radiochromic chloride was increased. These findings are compatible with increased gastrointestinal loss of plasma proteins. In addition, the patient had steatorrhoea. All of these abnormal findings were markedly improved after operative removal of the bezoar.