Video time lapse endoscopy.
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Anti-Ulcer Agents↗
Biomedical subjects
A Huppmann
Publications and source records attributed to A Huppmann.
Computer-assisted documentation and analysis of wound healing of the nasal and oesophageal mucosa.
Our aim was to analyse the dynamics of healing processes in the nose and oesophagus by videoendoscopic examination and reconstruction of the natural dynamics and continuity of a process using modern computer technology and so-called morphing software. Thirteen patients were followed-up for six months after sinus surgery and three weeks after oesophagitis. Four overlapping and meshing phases of wound healing following sinus surgery with significant interindividual differences. Topical budesonide shortened the duration of wound healing phases. Healing of oesophagitis occurred approximately symmetrically from the wound edges to the centre with constant velocity. Computer-assisted morphing enables dynamic analysing of mucosal processes under the following preconditions: Availability of a valid imaging method for documentation and measurement with the generation of congruent images. The process under analysis must run without sudden leaps and there must be adequate choice of timing of single measurement procedures.
Endoscopy↗
[Effects of postoperative care on wound healing after endonasal paranasal sinus surgery].
BACKGROUND: There is no standard for postoperative care after paranasal sinus surgery. METHODS: In a prospective study we evaluated the influence of modifications of postoperative care on wound healing after paranasal sinus surgery. We used a new method of documenting the natural dynamics of wound healing after endonasal paranasal sinus surgery that combines morphing and time-lapse video. Computer-assisted morphing means transformation of one shape into another by means of two-dimensional interpolation. The computer reconstructs the changes between the single frames taken by videoendoscopy at each examination by morphing. Editing all single frames from videoendoscopy and from morphing together resulted in a 60-second video showing wound healing over a period of six months. We documented wound healing 23 operations. Twelve patients with chronic polypoid sinusitis of similar extent were documented in a similar manner. Minimal postoperative care consisted of packing the operative cavity with rubber fingers for three days and irrigation with Ems brine. The effect of long-term packing and topical application of budesonide were studied. Analysis consisted of evaluating the time-lapse videos and final flexible endoscopy of the sinuses. RESULTS: Wound healing after complete endonasal sinus surgery varies greatly. In the first 7-12 days blood crusts covered the whole wound. Granulation was visible for 2-4 weeks. The increasingly edematous swelling reached its maximum in the 3rd-5th week and decreased in 7th-12th week. A macroscopically normal mucosa was observed from the 12th-18th weeks. Subepithelial changes occurred for longer than 6 months. CONCLUSIONS: The following measures are recommended for decreasing postoperative granulations, edema and swelling: minimizing the surgical trauma, long-term packing with a occlusive, nonadherent material (rubber finger packing), topical steroids (Budesonide). Stenosis of paranasal sinuses due to excessive scarring could not be prevented (especially in the frontal sinus).
Administration, Topical↗
[Dynamic imaging of gastric ulcer healing using the most modern Morph-Software].
The presentation of gastric ulcer healing taken from video endoscopy as a dynamic process could not be realized till now. The documentation of the dynamic healing process shattered either on the patient's compliance or on the inconstancy of the image cut due to wobbling. The replay should be performed as a time lapse whereby the picture disturbances would become an essential part.-Instead of presenting a continuous film, instant takes of ulcer healing were processed. A dynamic effect was produced by computer-assisted production of intermediate pictures. A video was created in which short video sequences in definite time intervals were recorded endoscopically. Single stills-so-called original pictures-fitting together from each sequence were selected and spliced together. The missing intermediate pictures were made with a special computer technique according to the mathematical concept of interpolation. With this technique, the dynamic documentation of gastric ulcer healing in a 47-year-old male patient was performed. The technique enables an almost natural and real observation of ulcer healing and promises new physiological and patho-physiological knowledge in gastroenterologic endoscopy.
Amoxicillin↗
[Imaging time-dependent changes in the nasal mucosa using the most modern morphing software].
Changes in the nasal mucous membrane lasting longer than 1-2 minutes have, until now, escaped dynamic observation. Even the congestion and decongestion of the turbinates during the nasal cycle and after application of vasoconstrictive nose drops have been documented only by instant stills. For this reason, we developed a method which permits documenting time-dependent endonasal mucosal changes with their natural dynamics on time-lapse video film. Instead of primarily recording a continuous video film, we processed instant stills. Computer interpolation of intermediate steps gives the viewer a dynamic impression. As continuous video endoscopy is not feasible, we produced the continuous film by recording video sequences of approximately 30 seconds length in defined time intervals endoscopically, selecting single stills (so-called original photographs) from each sequence, and splicing them, producing the missing intermediate photographs by a special computer technique (morphing), similar to mathematical interpolation. In this way we could demonstrate the changes of the right and left inferior turbinate during a nasal cycle of lasting five hours and the effect of xylometazolin nose drops on the nasal mucosa. The practical value of this technique, lies in the comprehensive realistic observation of dynamic processes of the nasal mucosa with respect to physiology and pathophysiology.
Adult↗