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Biomedical subjects

A I Bukhman

Publications and source records attributed to A I Bukhman.

At least 19 recordsLinked to original sources
PubMed1990

[The efficacy of proton irradiation of the hypophysis in children with Itsenko-Cushing disease].

The authors represent the results of the treatment of 20 children with Itsenko-Cushing disease (ICD) by proton-beam irradiation of the pituitary body. The use of the medical proton beam of the Institute of Theoretical and Experimental Physics was found to be effective for the treatment of children with mild and average forms of ICD. Irradiation of the pituitary gland at a dose of 70-100 Gy is accompanied by general and local radiation reactions which are not dangerous for children. The time of development of remission after irradiation depends on a degree of severity and features of a course of disease.

Adolescent↗
PubMed1989

[Radiotherapy in the treatment of children with Itsenko-Cushing's disease].

Forty children with Icenko-Cushing's disease were subjected to radiotherapy. Radiation of the pituitary with a proton beam in a dose of 70-100 Gy (7000-10000 rad) performed according to the indicated technique appeared highly effective. It was not associated with local or total radiation injuries and was safe. X-ray therapy conducted according to the fractionally intensive technique in a dose of 3000-3500 rad was less effective and produced disease relapses more frequently as compared with proton therapy.

Adolescent↗
PubMed1987

[Results of treatment of Itsenko-Cushing disease using proton irradiation of the hypophysis].

The application of protons (heavy charged particles) for irradiation of the pituitary body has some essential advantages over other types of teletherapy: insignificant destruction of surrounding tissues, a possibility of a single therapeutic session as well as the absence of post-radiation effects. Proton beam therapy was given to 98 patients with Icenko-Cushing disease aged 15 to 40. Mild cases were treated by proton beam irradiation only while severe cases were managed using proton beam therapy combined with unilateral adrenalectomy or oral administration of ortho-para-DDD. Catamnesis duration varied from 3 to 5 years. In most cases the exposure dose was 80-90 Gy (50-110 Gy). The procedure was well tolerated by all the patients. A dynamic multipolar converting method with 15-20 entrance poles in the left temporal area was employed (with the beam energy of 200 MeV). Stabilization of the course of disease and some clinical improvement were observed in most of the patients 3-4 months after proton beam therapy. In 6-36 months after irradiation 90% of the patients showed normal biochemical indices and the absence of any clinical signs of the disease. Three-five years after treatment, 94% of the patients were in steady remission. A 24-hour ACTH and cortisol normalization pattern was observed in all the patients in parallel with an increase in GH and gonadotropin secretion and a decrease in the prolactin level. Sex function renewal appeared to be the first clinical sign of remission. Young patients aged 15 to 20 with a short duration of disease reached remission faster than patients of the other age groups. Thus the results of proton beam therapy of 98 patients with Icenko-Cushing disease after a follow-up of 3-5 years showed a high efficacy of this type of treatment. The method can be used alone or in combination with unilateral adrenalectomy as well as with oral administration of ortho-para-DDD.

Adolescent↗
PubMed1980

[Indirect lymphography in the preoperative diagnosis of thyroid and parathyroid diseases].

The authors come to a conclusion that indirect lymphography is an effective method for the diagnosis of alterations in the thyroid gland (thyroiditis, malignant tumor, diffuse and nodular goiter). It can be also used in order to establish the state of its regional lymph nodes more exactly. The thyroid gland lymphography added by contrasting the esophagus is a simple and effective method for topical preoperative diagnosis and determination of localization of the altered parathyroid gland.

Adolescent↗
PubMed1977

[Complex diagnosis of breast diseases in a polyclinic].

In 159 patients with malignant and in 170 patients with benign tumors the diagnosis was established on the basis of clinical data, cytographic findings, obtained in puncturing the node and the results of roentgenological studies of mammary glands. In patients with malignant tumors all these methods yielded the similar results in 71.7% of cases, none of the methods concerned helped to diagnose the lesion in 2.5% of cases. The ultimate diagnosis in patients to be directed to the clinic coincided with histological findings in 97.5%. The coincidence of diagnoses, while using the mentioned three methods in patients with benign breast tumors was noted in 72.9% of cases. The methods under consideration failed to establish the diagnosis in 3% of cases. The ultimate diagnosis coincided with histological findings in 97.0%. The presence of negative results while using each of these methods is shown to be the characteristic of their resolving power.

Biopsy, Needle↗