[Changes in human liver microsomal oxidation under impulse aerodynamic effects].
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Biomedical subjects
Publications and source records attributed to A I Filatov.
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Impulse hydrodynamic influences (IHDI) resulted in an increase of accumulation of acridine organ, degranulation of neutrophils, decrease in adenylate cyclase and Na+, K+, Mg2(+)-dependent ATPase activities in the white blood cells of man and rat in vitro and in vivo. It was found that the cell's response to one-fold IHDI was more pronounced than to 5-fold IHDI. It was suggested that in certain conditions IHDI could lead to a decrease in reactivity of white blood cells.
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Impulse air waves (IAW) applied in non-destructive and weakly destructive intensities reduced the activity of lysosomal and microsomal enzymes as well as the activity of adenylate cyclase in the liver of laboratory rats. Five times repeated single application of IAW in intensities causing no noticeable biochemical (and morphological) changes led to shifts in the activity of rat hepatic enzymes. IAW which failed to produce a biological effect in humans when applied separately, inhibited noticeably antipyrine biotransformation in volunteers when applied repeatedly 80 times. It is concluded that the action of repeated subthreshold IAW is additive in character.
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