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Biomedical subjects

A I Frolova

Publications and source records attributed to A I Frolova.

At least 19 recordsLinked to original sources
PubMed1993

[The effect of antiaggregants on the course of diabetic microangiopathy].

As shown by conjunctival biomicroscopy, 6-month administration of ticlid and gliclazide induced a statistically significant increase in the frequency of less severe microcirculatory disturbances compared to conventional hypoglycemic therapy. The drugs also restricted plasmatic impregnation and cell proliferation in skin biopsy microvascular wall. Following 2-year antiaggregation treatment (gliclazide, trental, dipiridomol) 48.9% of diabetes mellitus patients achieved regression of morphological manifestations of diabetic microangiopathy, 16.2% stabilization against 34.9% of progressive disease cases. Conventional sugar-reducing therapy fails to stop diabetic microangiopathy progression in 73.4-93.3% of the diabetics.

Adolescent↗
PubMed1991

[The efficacy of the antiaggregants ticlid and diabeton in correcting chronic intravascular microcoagulation of the blood in diabetic patients].

Hemocoagulation was examined in 477 diabetes mellitus patients. Whatever the disease type, severity, duration and the intensity of microvascular complications, diabetes mellitus was discovered to be marked by the development of chronic intravascular blood microcoagulation associated with primary hyperactivation of the platelet component of hemostasis. The use of the new antiaggregation agents tiklid and diabeton allows an appreciable decrease of the activity of platelet microthrombus formation whereas the administration of the common sugar-reducing antidiabetic therapy favours the maintenance of its high level.

Adolescent↗
PubMed1990

[Quantitative changes of the blood serum immunoglobulins in patients with diabetes mellitus types I and II and microangiopathy detected by morphologic study].

A study was made of the immunological mechanisms implicated in the evolution of diabetic microangiopathy. For this purpose in 270 patients with type I and II diabetes mellitus, the concentration of IgA, IgM and IgG was measured and compared with morphological alterations in skin biopsy specimens. The control group was made up of 30 normal persons (donors). The sections were stained with conventional methods, which made it possible to reveal by light microscopy the correlation between the intensity of diabetic microangiopathy and the rise of the IgG level.

Adolescent↗
PubMed1987

[Results of a two-year clinico-morphological study of the natural evolution of diabetic microangiopathy and the efficacy of angioprotective therapy].

The authors analyzed the results of a 2-year study of a course of diabetic microangiopathy on the basis of clinical tests and morphological control over microvessels of skin biopsy specimens from 61 patients with diabetes mellitus, of whom 36 regularly received coronary vasodilators (diamicron, pentoxifylline and dipyridamole). The rest of the patients (25) with diabetes mellitus were taken as controls: 10 patients were with unsatisfactory compensation of diabetes mellitus and 15 with a stable metabolic control. A possibility of stabilization and regression of diabetic microangiopathy during prolonged regular administration of coronary vasodilators was shown.

Adolescent↗
PubMed1986

Elaboration and testing of insecticidal varnish in aerosol containers for the control of synanthropic cockroaches.

A formula for the filling of aerosol containers has been elaborated on the basis of a mixture of hexachlorocyclohexane (HCH) gamma isomer and tetrametrin, in a ratio 3:1 with the addition of furniture varnish NC-62 to produce the film, Khladon 11/12 (5050) served as propellent. The study of the process of crystallization of the insecticides on the surface of the film has shown that the effectiveness of insecticidal varnishes is the higher, the smaller the size of the crystals and the easier they can be removed from the surface of the film. This can be achieved by including tetrametrin along with HCH gamma isomer in the formula. The testing of the insecticidal activity and toxicity of aerosols prepared according to the elaborated formula has demonstrated high insecticidal activity of the composition with respect to synanthropic cockroaches and fairly low toxicity with respect to warm-blooded animals.

Aerosols↗
PubMed1986

[Status of cellular immunity in diabetic microangiopathy detected by skin biopsy].

As compared with normal persons, in 46 patients with diabetes mellitus there was a significant decrease in spontaneous leukocyte migration, a reduction in the absolute count of T-, B- and O-lymphocytes, and a rise in the relative count of D-lymphocytes. The disorders of cell-mediated immunity are formed during the first five years of illness. They do not depend on the diabetes severity, distinctly growing on with the appearance and increase of the degree of diabetic microangiopathy diagnosed on morphological analysis of skin biopsy specimens.

Adolescent↗
PubMed1986

[Participation of immune mechanisms in the development of microangiopathies in patients with non-insulin-dependent diabetes mellitus].

Biopsies of the thigh skin from 145 patients with immuno-independent diabetes mellitus were studied morphologically. Diabetical microangiopathy was found in 123 patients. IgG, IgM, complement, albumin, beta-lipoproteins, fibrinogen were determined immunohistochemically in the walls of altered vessels. The frequency of IgG fixation of the vascular wall and its level in the serum were significantly higher than in patients without alteration of small vessels. The conclusion on the leading role of plasmatic inhibition in the development of diabetic microangiopathy and on the participation of not only metabolic but also immune (immunocomplex most likely) mechanisms in its development is drawn.

Adult↗