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A I Gorbachevskaya

Publications and source records attributed to A I Gorbachevskaya.

At least 19 recordsLinked to original sources
PubMed2006

Organization of the efferent projections of the pedunculopontine tegmental nucleus of the midbrain of the dog pallidum.

Studies of the pedunculopontinopallidal projections of the dog brain based on the retrograde axonal transport of horseradish peroxidase demonstrated that the compact zone (PPNc) and the lateral area of the diffuse zone (PPNd) of the pedunculopontine tegmental nucleus (PPN) of the midbrain project to the globus pallidus, entopeduncular nucleus, and ventral pallidum. The medial area of the PPNd, adjacent to the chiasm of the upper cerebellar peduncles and seen in other animals as the mesencephalic extrapyramidal area (MEA), projects only to the globus pallidus. In dogs, this area of the tegmentum is not a major source of projections to the striopallidum, such that it is inappropriate to regard it as a separate structure, comment being restricted to the topical organization of PPNd projections to the pallidum. Projection fibers to pallidal structures arise from both cholinergic and non-cholinergic PPN neurons.

Animals↗
PubMed2005

Structural organization of the pedunculopontine nucleus of the tegmentum of the dog midbrain.

The aim of the present work was to perform cytoarchitectonic studies of the pedunculopontine nucleus (PPN) of the tegmentum of the midbrain in dogs to define the margins of this structure and to describe its separate substructures. The Nissl and Kluver-Barrera methods and histochemical detection of NADPH-diaphorase, this being a selective marker for cholinergic neurons in the tegmentum, were used to analyze the fiber organization, the morphological types of neurons, and the neuron density in the PPN of the tegmentum. This yielded a map of this nucleus in the dog with descriptions of the margins of its component zones: the compact and the diffuse. The mesencephalic extrapyramidal part could not be discriminated from the general composition of the PPN of the tegmentum.

Animals↗
PubMed2005

Organization of efferent projections of the pedunculopontine nucleus of the tegmentum of the striatum in the dog brain.

A method based on retrograde axonal transport was used to undertake detailed studies of the efferent projections of individual substructures of the pedunculopontine nucleus of the midbrain tegmentum to functionally diverse segments of striatal structures in dogs. The compact and diffuse zones of this nucleus were found to project to segments of the putamen, caudate nucleus, and nucleus accumbens, which are components of the limbic and motor systems. The medial part of the diffuse zone, adjacent to the decussation of the superior cerebellar peduncles (presumptively the mesencephalic extrapyramidal field) projected only to the dorsal segments of the caudate nucleus and putamen, which are parts of the motor system.

Animals↗
PubMed2004

Analysis of the morphological substrate for information processing in the striatum based on the organizational characteristics of its afferent projections.

Retrograde axonal transport of markers was used to study the afferent projections arising from functionally diverse cortical and subcortical structures and running to various segments of the caudate nucleus, nucleus accumbens, and putamen of the dog brain. The characteristics of the spatial organization of these projections were used to analyze the morphological aspects of the segregated and convergent conduction and processing of information in the striatum which underlie striatal function.

Afferent Pathways↗
PubMed2004

Organization of the thalamic projections of the striopallidum of the dog brain.

Experiments based on double luminescent labeling were performed to study the distribution of labeled neurons in the thalamic nuclei depending on the injection sites of luminescent markers into functionally similar or functionally different areas of the striopallidum of 16 dogs. The organizational characteristics of the thalamo-striopallidal projection system in dogs provide evidence for its high level of specificity, as not only the motor and limbic areas of the striopallidum, but also its functionally related areas, receive separate inputs mainly from diverse cellular groups. The centromedian nucleus contained groups of diffusely mixed cells, labeled with different markers and innervating functionally diverse segments of the caudate nucleus. In the centromedian, parafascicular, central medial, and medial dorsal nuclei of the thalamus, projection neurons form analogous cell populations innervating different segments of the striopallidal structures belonging to the same functional system. These striopallidal areas receive projections from small numbers of neurons via axon collaterals.

Afferent Pathways↗
PubMed2003

Analysis of the structural bases of information processing in the basal ganglia: the spatial organization of thalamocortical projections in the dog brain.

Analysis of the architectonics of the thalamic projection systems of the caudate nucleus, putamen, and nucleus accumbens using axonal transport of retrograde markers was performed to study the morphological substrate for information processing in the striatum of the dog brain. The striatal nuclei contained areas through which segregated conduction of motor (dorsal segments of the caudate nucleus and putamen) and limbic (medial segment of the nucleus accumbens) information could occur, along with areas (ventral segments of the caudate nucleus and putamen, lateral segment of the nucleus accumbens) in which convergent conduction of functionally diverse information processed in the thalamic nuclei could occur. These data make a significant contribution to our understanding of the anatomical aspects of both the functional heterogeneity of the basal ganglia and integrative information processing occurring within them, which underlies the mechanisms organizing adaptive behavior.

Animals↗
PubMedDate not supplied

Functional details of the basal ganglia as related to the spatial organization of their fibers in cortex and thalamus.

This study compared the results of experimental-morphological and physiological studies in which facts were obtained regarding the functional and morphological heterogeneity of the basal ganglia. Experiments were done on dogs in order to study delayed responses and Hunterian delayed choice responses. Electrical and chemical stimulation of striopallidal structures and recording of spike activity in neurons were done in cats during the formation of conditioned reflexes. Morphological studies were done on cats and dogs by the technique of axon-terminal degeneration. On the basis of an analysis of our own data and data in the literature we have advanced the hypothesis that: 1)There is a correlation between the general features of the disturbance in higher nervous activity and the overlap of striopallidal projections onto cortical and thalamic structures; 2) in a series of cases the behavioral disturbance after shut-off or stimulation of the thalamic structures; 2) in a series of cases the behavioral disturbance after shut-off or stimulation of the basal ganglia can be correlated with the topical details of their projection onto cortical fields and thalamic nuclei.

Animals↗
PubMedDate not supplied

Participation of glutamatergic and dopaminergic systems of the neostriatum in the organization of alimentary conditioned reflexes.

In this study the results of behavioral, neurophysiological, and morphological investigations in relation to the participation of the corticostriatonigral system in the organization of conditioned reflexes are presented. It was demonstrated in experiments on dogs that blockade of N-methyl-D-aspartate receptors of the caudate nucleus disrupts the realization of consolidated conditioned reflexes and renders their development more difficult. The blockade of quisqualate receptors facilitates the process of differentiation. Switching off of the dopaminergic input makes the development of positive conditioned reflexes more difficult. The reversible switching off of the substantia nigra leads to the reorganization of the neuronal activity of the caudate nucleus in response to the presentation of the conditional signal. Inhibitory nigral influences are directed primarily to the ventromedial divisions of the nucleus, while activating influences are directed to its dorsal segments. The topically organized connections of the motor regions of the cortex with the dorsal region of the caudate nucleus, and of the limbic regions with its ventromedial divisions were studied in morphological investigations on cats. A certain distinctiveness was identified of the spatial organization of the nigrostriatal projections. The data obtained are discussed from the point of view from the systemic organization of behavior.

Animals↗
PubMedDate not supplied

Structural basis of the interaction of the limbic and motor systems in the striopallidum.

The results regarding the topical organization of the projections from the nuclei of the amygdaloid body, the ventral tegmental area, and the substantia nigra in the striopallidum were generalized and compared in a study carried out on 125 cats, using the method of retrograde axonal transport of horseradish peroxidase and fluorochromes. Limbic and motor areas were identified in the basal ganglia with a predominance of projections, respectively, from the subcortical structures belonging to the limbic system, or from formations relating to a greater degree to motoric activity. In addition to this, the overlapping of terminals of the fields of the initial neurons of these and other structures was established in substantial areas of the striopallidum. The data obtained regarding the organization of projections of functionally varied subcortical formations to the striopallidum suggest that it may be regarded as the structural basis of the functional heterogeneity of the basal ganglia and of the interaction of the motor and limbic systems in them.

Afferent Pathways↗