[The method of integral estimation of a functional status of the hemostatic system].
The instrumental method of the integral assessment of functional state of the hemostasis system using piezoelectric hemoviscosigraphy was elaborated.
Biomedical subjects
Publications and source records attributed to A I Gozhenko.
The instrumental method of the integral assessment of functional state of the hemostasis system using piezoelectric hemoviscosigraphy was elaborated.
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Indices of hemodynamics, some renal functions and mechanisms of their regulation were studied in 29 patients with ischemic heart disease and chronic circulatory insufficiency (grade IIA) and in 27 healthy persons under load conditions. Indices of central hemodynamics and renal function deteriorated in the patients after increase of preloads while there were no essential changes of the activity of renin-angiotensin-aldosteron activity.
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The peptide material of the 2nd and 3rd fractions of the natriuretic factor did not affect the passive sodium transport while inhibiting the active transport in slices of the rat kidney cortex. This inhibition was accompanied by a decrease of both the succinic dehydrase system and Na+, K+-activated ATPase activities in the slices. The natriuresis caused by the natriuretic factor seems to be due to the inhibition of the active sodium transport.
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Density was studied of heat flow from the area of the anterior abdominal wall in 167 patients with acute appendicitis. A novel methodological approach has been developed to the diagnosis of acute appendicitis making use of remote thermometry with the unit "Radiation heat flows meter". Recording of heat flows from the region of the anterior abdominal wall helps in the diagnosis of acute appendicitis, allows some preliminary judgement about the degree of affection of the organ, permits choosing relevant policy of managing a particular patient. The method can be employed in planned and urgent surgery.
The effects of prostacyclin and its stable analogue MM-706 on renal function were examined in rats with sublimate nephropathy. Prostacyclin was shown to attenuate renal dysfunctions by increasing glomerular filtration rate and water and salt reabsorption. MM-706 produced more pronounced protective effects and restored the filtration and reabsorption up to the level observed in control rats.
The influence of a stable analogue of prostacyclin on the renal function and parameters of hemostasis was investigated in experiments on animals with the nephrotic form of acute renal insufficiency. Diuresis, glomerular filtration, water and sodium reabsorption in the presence of diminished intravascular coagulation were recovered after two injections of the compound in a dose of 115 micrograms/kg.
A conclusion on relationships of the septum with both the antidiuretic and antinatriuretic systems in the regulation of the aqueous-electrolytic balance and renal function has been drawn as a result of the study of the drinking behaviour and renal reaction after the destruction of the lateral septal nucleus (LSN). This conclusion is based on the revealed increase in the urinary excretion of sodium, osmotically active substances, creatinine, titrating acids and ammonia after the LSN destruction. Moreover, an increase of the vasopressin level in the blood plasma, a decrease of aldosterone concentration as well as an activation of the drinking behaviour are noted.
During the acute experimental nephritis a decrease of reabsorption by proximal tubules is combined with the activation of the lipid peroxidation into the renal cortex without changes in the activation of lysosomal enzyme of acid phosphatase and cathepsin D. Ionol, an inhibitor of oxygen products, exerts a protective action on the renal function and reabsorption by proximal tubules, decreasing concentration of the malondialdehyde into the renal cortex.