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Biomedical subjects

A I Gozhenko

Publications and source records attributed to A I Gozhenko.

49 records · Page 3Linked to original sources
PubMedDate not supplied

[Role of breast feeding in providing the newborn infant with thyroid hormones].

Radioimmunoassay was conducted to study the content of triiodothyronine and thyroxine in the human milk and in the blood serum of mature and premature newborns. It was established that with the growth of the lactation period the content of triiodothyronine and thyroxine rose; it was, respectively, 0.5 +/- 0.12 and 100.3 +/- 8.4 nmol/l in colostrum, 9.2 +/- 0.7 and 271.3 +/- 14.1 nmol/l in transient milk, 11.1 +/- 1.07 and 405.0 +/- 21.4 nmol/l in fully formed milk. Fully formed milk contains three times more triiodothyronine and thyroxine than the blood serum of newborns. The mature newborns have a sufficiently formed thyroid function. The level of thyroid hormones in the blood serum of premature newborns is decreased in proportion to the stage of their prematurity. They receive the deficient hormones through the human milk. The authors recommend that the nutrition of premature newborns receiving mixed and artificial feeding should be supplemented with thyroid hormones.

Breast Feeding↗
PubMedDate not supplied

[Effect of progesterone on the ion-regulating function of the kidneys].

The effect of progesterone on ion-regulating kidney function was studied in experiments on albino male rats under the conditions of spontaneous and water diuresis. Kidney function was evaluated by the level of urination, sodium, potassium and creatinine excretion with regard to the glomerular filtration and tubular reabsorption in water diuresis. Five series experiments were made, including a study of the effect of progesterone on kidney function under the conditions of a low and high sodium diet, adrenalectomy and castration. Progesterone was shown to possess a pronounced natriuretic effect in sodium deficiency in the body and to cause sodium retention in a high sodium diet. Adrenalectomy and castration did not prevent the natriuretic action of progesterone. The elevated excretion of sodium was determined by an increase in its filtration charge. In all the studies sodium excretion changed with a sufficient degree of significance (P less than 0,01 = PI less than 0,05).

Adrenalectomy↗
PubMedDate not supplied

[Isolation of fractions containing natriuretic hormone from blood plasma and their testing in in vivo and in vitro experiments].

Natriuretic hormone (NUH) was isolated from the canine arterial blood plasma by means of gel chromatography on sefadex G-25. The plasma was preliminarily deproteinized with trichloro-acetic acid and the supernatant layer was lyophilized. Five peptide fractions were obtained by means of spectrophotometry in UV spectrum at 280 microns. The 2nd and 3d fractions of this material had a natriuretic activity in experiments on rats. The same fractions inhibited short-circuit current and the frog skin potential, as well as the frog skin oxygen consumption. For the present it is unlikely to confirm that this natriuretic activity should be caused by one or different chemical substances due to inaccurate separation of the 2nd and 3d fractions. The methods of a study of short-circuit current and the frog skin potential as well as a polarographic study of the frog skin oxygen consumption can be used for NUH testing.

Animals↗
PubMedDate not supplied

[Mechanisms of renal adaptation to disorders of water-electrolyte balance in metabolic acidosis].

The albino rat experiments have demonstrated that despite the type, metabolic acidosis causes an increase in plasma and urinary osmolarity, hyperkalemia and hypernatremia, enhanced urinary excretion of potassium, phosphates, and titrated acids with a tendency for the glomerular filtration rate and urinary pH to be lowered with the increased concentrations of plasma vasopressin and insulin and renal cortical PGE2. Hyperchlorinemic acidosis without increases in the anion difference is accompanied by severe chloremia, natriuresis, chloruresis, ammoniuresis without diuretic changes with the inhibited renin-aldosterone system and progesterone synthesis. Lactate acidosis with a growing anion difference leads to lower diuresis, Na+ and Cl- excretion without enhancing ammonium excretion in the presence of elevated plasma levels of renin, aldosterone, and progesterone. It is concluded that in metabolic acidosis, adaptation to water-electrolytic exchange derangements greatly depends upon the type of metabolic acidosis and it is mediated by hormones to a considerable extent.

Acidosis↗
PubMedDate not supplied

[The efficacy of metabolic therapy in chronic gastritis with secretory deficiency in flight personnel].

Overall ninety individuals (all males) of flying personnel 22 to 45 years old were examined under inpatient medical care facility conditions. Diagnosis of chronic gastritis (ChG) was confirmed with the aid of fibrogastroduodenoscopy, histologic, histochemical (periodic acid-Schiff reaction) sections of aimed biopsy specimens of gastric mucosa (GM), as well as by the use of euphyllinum, histamine while studying gastric secretion. Distinguishing features were noted of the ChG course as were their relatedness to the aircrew activity. On completing the metabolic therapy involving use of calcium gluconate, euphylline, panangine, 24 ChG patients presenting with secretory deficiency enjoyed clinical, metabolic, acid-producing effect superior to that of replacement therapy.

Adult↗
PubMedDate not supplied

[The use of otsid in treating patients with chronic gastroduodenitis and duodenal peptic ulcer].

Data are submitted of examination of 56 individuals (50 men and six women) in a clinical and diagnostic consultation center setting. The diagnosis was confirmed by results of fibrogastroduodenoscopy, ultrasonography of the abdominal organs, assay of the gastric secretion in endoscopic pH-metry, microscopic examination of smears-imprints for the presence of Helicobacter pylori in gastric mucosa. A comparative evaluation was done of efficacy of the course administration of ocide (omeprasole) in 26 patients with duodenal ulcer and 30 patients with chronic gastroduodenitis presenting with augmented secretion.

Adult↗
PubMedDate not supplied

[The protective action of alpha-tocopherol on kidney function and lipid peroxidation in acute hemic hypoxia].

As shown in experiments on 54 noninbred white male rats, activation of lipid peroxidation in renal cortical substance contributes to impairment of renal function in acute hemic hypoxia. Administration of alpha-tocopherol promoted stimulation of renal protection: reduced the degree of proteinuria, sodium excretion, enhanced proximal reabsorption of osmotically active substances and sodium, glomerular filtration. This was accompanied with increased activity of superoxide dismutase and lowering of malonic dialdehyde concentration in renal cortical substance.

Acute Disease↗