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Biomedical subjects

A I Johnson

Publications and source records attributed to A I Johnson.

2 recordsLinked to original sources

Using the continuous quality improvement process to safely lower the cesarean section rate.

BACKGROUND: In 1994 a five-year prospective observational study (including 38,541 singleton live-born deliveries) based on maternal and neonatal hospital administrative discharge data for DRGs 370-375 was launched at Cedars Sinai Medical Center (CSMC) in Los Angeles. In 1993 a cesarean section (C-section) reduction task force was first convened and several interventions were conducted and monitored during a two-year period. In 1995 CSMC joined the Institute for Healthcare Improvement's (IHI's) national collaborative on lowering C-section rates. RESULTS: The first intervention involved physician education (grand rounds) and occurred during the preintervention baseline period. Providing physician-specific data had been implemented before participation in the IHI collaborative. Two other interventions were implemented before the collaborative versus 13 interventions after. The C-section rate decreased from 26.0% in the baseline period in 1993 to 20.5% in 1997, a 21.2% reduction. During the postintervention period, the C-section rate increased to 23.5%. There was no statistically or clinically significant increase in clavicular fractures, brachial plexus injuries, or cerebral hemorrhage in the four study years, compared to the baseline period. DISCUSSION: It is possible to safely reduce C-section delivery rates. Activities are now under way to involve additional private physician leaders in the continuous quality improvement effort. Although the small increase in the C-section rate during the postintervention period may represent statistical variation, and in itself may not be clinically significant, it supports the thesis that ongoing, continuous organizational support is required to achieve and maintain gains.

Adult↗

Hormonal control of sexual attraction in pseudohermaphroditic female dogs.

Groups of female dogs exposed to different degrees of androgenic stimulation during development and a control group of ovariectomized females were tested for their attraction to tethered male and female stimulus animals. Attraction to the male was measured before and after administration of estradiol, and attraction to an estrous female was tested before and after administration of testosterone propionate (TP). Time spent visiting the tethered male was approximately equal for all groups prior to hormone treatment, but after receiving estradiol, control females exhibited a pronounced increase in visiting time; the second longest visits were paid by females that had received moderate amounts of androgen before birth; more heavily androgenized females exhibited no increase in attraction to the male despite estradiol injections. Visits to the estrous female before administration of TP were longer for some groups than for others, but there was no relation between the degree of perinatal androgenization and mean visiting time. After injections to TP the most pronounced increase in visiting was shown by females that had received the largest amounts of androgen during development, and the second largest increase occurred in the prenatally androgenized group. Control females showed the smallest increase in visiting time.

Age Factors↗