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Biomedical subjects

A I Machula

Publications and source records attributed to A I Machula.

27 records · Page 2Linked to original sources
PubMedDate not supplied

[Mediator nature of the action of cathinone on animal behavior].

The influence of catinon on visual differentiation was studied in cat experiments by the methods of conditioned avoidance. It turned out that catinon (1 mg/kg) worsened the differentiation of both short and prolonged visual stimuli. These effects of catinon were potentiated when the serotoninergic system was activated and were weakened when the dopaminergic system was activated.

5-Hydroxytryptophan↗
PubMedDate not supplied

[Monoaminergic component in the effect of D-9-tetrahydrocannabinol on conditioned reflex activity].

The involvement of monoaminergic system in the realization of the effect of D-9-hydrocannabinol on different parameters of the conditioned reflex was examined on cats. It appeared that the effect of D-9-cannabinol on the differentiation of long-term and short-term stimuli depends but to a different degree on the activity of both the serotoninergic and catecholaminergic systems. The effect of D-9-tetrahydrocannabinol on the rate of the performance of the conditioned reflex depends on the activity of the dopaminergic system.

Animals↗
PubMedDate not supplied

[Effect of delta 9-tetrahydrocannabinol on cortical evoked potentials].

It has been shown on cats with the help of the registration of evoked potentials of the visual, somatosensory and associative areas of the brain cortex that delta-9 tetrahydrocannabinol in a dose of 1.5 mg/kg diminishes the amplitude of the primary responses in all the areas whereas in a dose of 3.5 mg/kg it influences both early and late components of evoked potentials interfering with their similarity in the definite areas of the brain cortex.

Animals↗
PubMedDate not supplied

[Visual discrimination characteristics under the action of psychostimulants].

It was shown in cats by the method of conditioned defensive reflexes that phenamine (0.5 mg/kg), sydnocarb (3 mg/kg) and katinon (1 mg/kg) accelerate realization of the conditioned defensive reflex, but abolish the differentiation of visual stimuli. While producing a similar effect, cocolen (1 mg/kg) does not abolish the differentiation of visual stimuli.

Alkaloids↗
PubMedDate not supplied

[Characteristics of the excitation changes in the visual area of the cerebral cortex under psychostimulant action].

The experiments were carried out on cats with chronically implanted electrodes. It was shown by means of recording the primary responses (PR) of the visual cortex that amphetamine (0,5 mg/kg), sydnocarb (3 mg/kg), and catinon (1 mg/kg) depress the amplitude of the single PR and lessen concurrently the depression of the testing response in the cycle of PR recovery. Cocaine (1 mg/kg) suppresses the amplitude of the single PR and intensifies the depression of the testing PR in the recovery cycle.

Animals↗