The frequency and nature of the main signs of Icenko-Cushing's syndrome were studied in 132 patients divided into 4 groups with relation to morphological changes in the adrenals. It was established that the peculiarities of morphological structure of the adrenals were not reflected in a clinical picture of disease. A more frequent development of some clinical manifestations of Icenko-Cushing's syndrome was noted in the group of patients with a significantly higher mean level of cortisol in the blood plasma. The test with 8 mg of dexamethasone for suppression of 17-OCS excreted with urine was not strictly specific for any stage of morphological changes in the adrenal cortex.

17-Hydroxycorticosteroids↗

PubMedDate not supplied

[Similarity and differences of the pathogenesis of Itsenko-Cushing syndrome variants].

Proceeding from a study of the results of the investigation of 152 patients with Icenko-Cushing's syndrome the authors have arrived at the conclusion that hyperplasia, clear cell adenoma of monomorphous structure, dark cell and mixed adenomas of polymorphous structure, cancer of the adrenal cortex are different stages of a common pathological process. Such formation of morphological changes in the adrenal gland is one of the ways of development of Icenko-Cushing's syndrome. To confirm the proposed concept of the pathogenesis of this disease the authors provide some evidence of hyperplasia or the normal structure of nontumorous adrenocortical tissue in adenoma and cancer, of the absence of difference in a rise of the mean ACTH level in the blood in hyperplasia and different adrenocortical tumors. An increase in ACTH production in most of the patients should be regarded as one of the primary factors of the above morphological changes. The absence of suppression of 17-oxycorticosteroid excretion with urine in a test with 8 mg of dexamethasone in most of the patients with dark cell and mixed adenoma of polymorphous structure and adrenocortical cancer suggests a possibility of the development of certain autonomy of these neoplasms.

17-Hydroxycorticosteroids↗

PubMedDate not supplied

[Diagnostic possibilities for computer tomography in adrenal diseases].

Explore the source record for details and available documents.

Adrenal Gland Diseases↗

PubMedDate not supplied

[The late results of surgical interventions in radically inoperable stomach and colonic tumors].

The long-term outcomes of palliative operations and diagnostic laparotomies in 98 patients with radically inoperable cancers of gastric-intestinal tract are analysed. Increased blood oncoantigene parameters are not to be considered as subclinical markers of oncological process. Though complex assessment of cancer patients' curability the parameters of oncoantigene content may occur to be useful in determination of the prognosis of life longitude of patients having undergone the primary tumour focus removal.

Adult↗