[The diagnosis of malignant pleural mesothelioma].
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Biomedical subjects
Publications and source records attributed to A I Pozmogov.
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A complex examination of 1400 patients with pathologies of the lungs and mediastinum was carried out using roentgenologic, endoscopic, bioptic and cytologic methods. Diagnosis was confirmed morphologically in 93.7% of cases. More specific information was obtained by express cytologic examination in 97.9% of cases of malignant growth and in 64.4% with benign tumors. On the basis of the test results, preoperative intratumor chemotherapy technique suggested by the authors may be recommended for clinical use.
The complex examination of 1400 patients with pathologic masses of the lungs and mediastinal organs with the use of roentgenologic, endoscopic, puncture bioptic and cytologic methods was carried out. Morphologic verification of diagnosis was performed in 93.7% of the patients. In express cytologic study, histogenesis of neoplasms of the thoracic cavity organs was specified in 97.9% of cases of a malignant tumour, and in 64.4% of those of a benign one.
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Half-body irradiation at a single dose of 400-800 cGy was delivered to patients with disseminated fast-growing types of lymphomas and large aggregates of tumors and vital dysfunction of the body (the compression syndrome). Active detoxification therapy including heparinization, hemodilution with enforced diuresis and hemosorption was performed to prevent the syndrome of acute tumor lysis and postradiation complications. This treatment modality resulted in the elimination of clinical manifestations of the compression syndrome, normalization of the body homeostasis, a considerable reduction of the volume of tumor aggregates on a short-term basis, entering the patients into a curable state; the 5-year follow-up results were evaluated.
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