Biomedical subjects
Publications and source records attributed to A I Ryzhov.
Exposure to X-rays causes pronounced morphofunctional changes in basal cells and modulates linear cellularity in the epidermal basal layer in guinea pigs. Radiosensitivity of skin basal cells of different location is different: the most pronounced morphofunctional changes were observed in the skin of the head (cheek) and abdomen.
Involuntary evacuation of the stoma is the problem of social rehabilitation of stomed patients. In 17 patients during formation of colostoma reservoir-holding mechanism was created. Strain of parietal peritoneum led to subjective feelings predicting colostoma evacuation that were seen 10-20 min before defecation and presented as heaviness in projection of external end of stoma in 15 (88.2%) or elements of intestinal colic in 2 (11.8%) patients. This permitted 9 patients to control colostoma evacuation. Five (29.4%) patients demonstrated ability to control defecation for 10-15 min with tension of the muscles of the anterior abdominal wall.
We studied morphological changes in hyaline cartilages of different localization in adult male rabbits with focal persistent infection produced by Staphylococcus aureus strain 209. Local chronic inflammation produced systemic atrophic and degenerative changes in the cartilage tissue. The severity of pathological changes depended on genetically determined repair and metabolic activity of the cartilage tissue.
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Organ complexes of bats (Nyctalis noctula), consisting of oesophagus, stomach and initial part of the small intestine have been subjected to histological and morphometrical investigation. As demonstrates the histological investigation of the preparations, the denticulate line of the mucous membrane of the oesophageal-gastric passage is displaced towards the stomach. In the cardia a well manifested internal sphincter has been revealed. In the place, where the stomach passes into the small intestine, on a small area of the submucosal tela of the intestine, there is an accumulation of secretory parts of the duodenal glands. They form a glandular torulus, which narrows the transitional zone lumen. A peculiarity of the bat pylorus is absence of an anatomical sphincter in it.
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The effect of antitumour antibiotics, such as rubomycin and karminomycin on the digestive tract as one of the most vulnerable systems during chemotherapy was studied. Investigation of the tongue, oesophagus, stomach, small and large intestine of mice with the current morphological and some histochemical methods showed that the most pronounced changes in the above organs occurred during the first 10 days after the drug administration. The damages were of the same type, i.e. dystrophic changes in the tegmental and granular epithelium with edema and infiltration of the mucosa and tunica submucosa. The drugs induced a decrease in the levels of the nucleic acids, protein and hydrolytic enzymes and impairement of the distribution pattern of these substances in the cells. Karminomycin had a more pronounced effect and its damaging effect was more stable as compared to rubomycin.
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Rat experiments with ether anaesthesia (EA) indicate that EA induces enlargement of hepatic sinusoids, stasis and perivascular edema of the triad vessels and other changes in the liver. Right hypochondrium exposure to electromagnetic waves (4.76-5.08 mm) up to 20 days in rats given simultaneously ether anaesthesia showed that livers from the irradiated rats did not differ from control. Thus, millimetric wave radiation may prevent pathological alterations arising in white rat liver after ether anaesthesia.
Activation of peripheral mu-opioid receptors contributes to an increase in stability of cardiomyocytes to stress damage manifesting with decreased accumulation of Tc-99m pyrophosphate in the heart muscle and contractures of the myocardium. As a principal mechanism of mu-receptor-dependent increase in resistance of the heart to stress damage, modulated influence of opioids on adrenergic pathogenetic links of heart stress damage is considered. In realization of the discovered cardioprotective effect associated with mu-receptor activation, opioidergic limitation of histamine release from mast cells in the myocardium and also mu-receptor-dependent intensification of coronary bloodstream in stressed animals may play a definite role.
The results of studying an effect of microwaves on the different regions of visual analyzer are investigated. The morphofunctional changes at the light-optic and electron-microscopic levels are revealed. The changes involve not only peripheric area of visual analyzer but also its central regions. Some epidemiologic observations are indicative of: altered sizes of blind spot; decreased magnitudes of optic rheobase and chronaxy; color vision disorder; increased diastolic pressure in central artery of the retina. Study of bioelectrical activity of the retina enabled some investigators to make a conclusion about a reaction disorders occurring in the subcortical visual centers. It is noted that the animal studies not always explain unequivocally the microwave effects on the visual analyzer.