MINUTE CHROMATIN BODIES IN MALIGNANT TUMOURS OF CHILDHOOD.
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Biomedical subjects
Publications and source records attributed to A I SPRIGGS.
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Smears and sections were obtained from various labelled points on the mucosal surface of 25 freshly-excised stomachs, and the appearances were compared. Normal gastric mucosa, intestinal metaplasia, chronic gastritis, and carcinoma could generally be identified from the smears. In a few smears from the edge of peptic ulcers there were abnormal cells which might cause confusion with carcinoma. Conversely, tumour cells were seen which would be very hard to diagnose with certainty on cytological grounds.
White-cell concentrates were made by a dextran sedimentation technique from the blood of 140 cases of malignant disease and 60 controls. The slides were searched for tumour cells and for other unusual cells with which they might be confused. Several million white cells were scanned in the slides from each case. Acceptable tumour cells were identified in the blood of seven patients, none of whom survived for more than a few months. These cells are illustrated, as well as various other cell types which may have been confused with malignant cells in the past. It is concluded that the cytology of white cell concentrates should be further explored before statistics about the occurrence of circulating tumour cells are accepted.
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