PubMed Health⌕ Search

Biomedical subjects

A I Speranskiĭ

Publications and source records attributed to A I Speranskiĭ.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Seronegative rheumatoid arthritis in adolescents].

Of 116 persons who developed rheumatoid arthritis (RA) as teen-agers, 56 were seronegative for RF a long period of time. Clinicolaboratory and x-ray manifestations in this group of patients were analyzed. Adolescents with seronegative RA presented a heterogeneous group requiring further investigation.

Adolescent↗
PubMed1987

[Importance of the determination of antibodies to n-DNA in systemic lupus erythematosus and other rheumatic diseases (comparative study of radioisotope and immunoenzyme technics)].

Altogether 95 patients with systemic lupus erythematosus, 36 patients with rheumatoid arthritis, 10 with sclerodermia systematic, 10 with Bekhterev's disease, 9 with rheumatic fever, and 20 healthy persons were examined. An analysis of the results made it possible to establish that in SLE, sclerodermia systematic and Bekhterev's disease the frequency of detection of higher levels of antibodies to n-DNA using enzyme immunoassay and radionuclide methods was approximately the same. SLE patients were characterized by a 2-fold increase in the level of antibodies to n-DNA as compared to patients with sclerodermia systematic, Bekhterev's disease and rheumatic fever suggesting usefulness for differentiation of these diseases. In rheumatic fever and rheumatoid arthritis antibodies to n-DNA in minimal elevated levels were revealed more frequently under enzyme immunoassay than in radionuclide ones. In SLE high levels of antibodies to n-DNA under the method of radionuclide binding showed significant correlation with a decrease in complement hemolytic activity, high levels of circulating immune complexes, with a higher frequency of detection of the antinuclear factor, and reflected lupus nephritis severity. Enzyme immunoassay used for the detection of antibodies to n-DNA showed correlation of high levels of these antibodies with signs of developing cerebrovasculitis and pulmonary lesion.

Adolescent↗
PubMed1984

[Possibilities for using the analytical ultracentrifugation method for determining circulating immune complexes in rheumatic diseases].

Analytical ultracentrifugation was used to study circulating immune complexes in 78 patients suffering from different rheumatic diseases. Using this method immune complexes were mostly detectable in patients with rheumatoid arthritis. This correlated with the disease activity, roentgenological stage of articular involvement, development of the systemic manifestations associated with rheumatoid vasculitis. Demonstration of immune complexes by analytical ultracentrifugation was found to correlate on the whole with the presence in sera of high titers of rheumatoid factors and immune complexes according to the PEG method data.

Adolescent↗