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Biomedical subjects

A I Zotin

Publications and source records attributed to A I Zotin.

At least 19 recordsLinked to original sources

Phenomenological theory of ontogenesis.

In accordance to Prigogine-Wiame and phenomenological theories of ontogenesis, a continuous decreasing of specific entropy production measured by the intensity of heat production or respiration takes place during development, growth and aging. There are periods in the life of organisms when reverse processes occur: (initial stages of oogenesis, regeneration and malignant growth). The phenomenological theory of ontogenesis demonstrates that physical bases of individual development are characterized by two thermodynamic principles: minimum energy dissipation and fastest descent.

Aging↗

Aspects of bioenergetics and civilization.

By means of an allometric relation between the oxygen consumption rate and the body mass of an animal a metabolic coefficient is derived that can be used as a measure of standard metabolism in different animal species. This coefficient increased in the course of evolution corresponding to the time of appearance of each class of animal. It reached its highest values in Primates and passerine birds. A further increase across an energetic threshold was only possible with human civilization. A similar approach to evolution is performed through an encephalization coefficient showing that in all phases of evolution, species existed with a much larger relative brain volume than the other members of their class. These species might have established a non-human civilization on Earth if evolution would have taken another path. Finally, social activities of insects and the use of external energy sources by animals are discussed to show further implications of this bioenergetic approach to evolution.

Animals↗

Experimental investigation of the bound dissipation function: change of the psi u-function during the growth of yeast.

By means of a microcalorimeter (direct calorimetry) and a Warburg-apparatus (indirect calorimetry) that part of the dissipation of a growing culture of yeast cells which remains irreversible in the cells is determined (psi u). The course of the psi u-function with time correlates with the increase of the specific cell concentration being conditioned by the growth phase of the culture but similar for fermentative and respirative metabolism.

Aerobiosis↗

Relationship between respiration rate and weight of loach oocytes.

It is shown that the constant k in the equation QO2 equals apk and the constant b in the equation qo2 equals aP-b change during the oogenesis of the loach. Hence, the growth of oocytes differs considerably from the growth of animals, where the constants k and b do not change with increase in weight. It is suggested that the relationship between the respiration rate and weight of the oocytes is due to the change in the amount of mitochondria in the oocytes.

Animals↗

[Heat production and respiration of the oocyte of Xenopus laevis L. in various stages of oogenesis].

The data are given on the respiration and heat production intensity in the X. laevis oocytes by which the value and patterns of change of psiu-function (function of bound dissipation) during oogenesis are calculated. All 3 values were shown to decrease rapidly from the stage of previtellogenesis till the stage of mature oocyte what agrees with the thermodynamic theory of development.

Animals↗