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Biomedical subjects

A Ia Akimova

Publications and source records attributed to A Ia Akimova.

At least 19 recordsLinked to original sources
PubMed1993

[The effect of absorbent materials with drugs on wound healing].

Absorptive hydrophilic materials (MAH) containing dioxydin and terrilytin as drug components were studied in experiments on guinea pigs infected with K-11 strain of E. coli. The results showed that the wounds in animals who did not receive treatment were cleaned by the 14th day, while the wounds in animals treated by applications of MAH with dioxydin and terrilytin became clean on the 3rd day, i. e. 5 times quicker. Absorptive hydrophilic materials containing dioxydin and teriilytin were easily handled, easily applied and removed, they did not injure the granulation tissue, and intensified growth of peripheral epithelialization. Thus, experimental study showed absorptive hydrophilic materials containing dioxydin and terrilytin to be highly effective in the treatment of purulent wounds, which allows them to be recommended for clinical use.

Administration, Topical↗
PubMed1991

[Endoscopic glue infiltration and diathermocoagulation in the complex treatment of patients with acute gastroduodenal hemorrhages].

A special medicinal glue MIK-T capable of infiltrating biological tissue by means of an endoscopic needle was developed. The authors suggest a method for glue endoscopic infiltration of the source of gastroduodenal bleeding for its arrest and prevention of a recurrence. Experimental study was undertaken to study the efficacy of glue endoscopic infiltration, determine the terms of glue resolution, and reveal the morphological changes in the zone of glue injection. The method of glue endoscopic infiltration was employed in complex treatment of 109 patients with acute gastroduodenal bleeding. The results provide evidence of the high efficacy of the method and its advantages over diathermocoagulation in arresting and preventing recurrences of acute gastroduodenal bleeding.

Acute Disease↗
PubMed1990

[Use of cytostatics in polymer-drug complexes in the treatment of malignant neoplasms of the maxilla].

The authors analyze the efficacy of antitumor drugs deposited with cyanoacrylate adhesive solution in therapy of Stages III-IV maxillary tumors. Immediate and late results of therapy with these compositions of 21 patients evidence that such treatment is not associated with the wound or general toxic complications and that wounds may be managed without tampons. Deposition of the drug and its regulated elimination from the composition helps create a high concentration of the agent at the operation site where the tumor elements remained after surgery; this permits expecting better late results.

Adult↗
PubMed1989

[Local administration of contrical in the complex treatment of gastrointestinal ulcers].

The authors report the results of experiments and of multiple-modality treatment of gastroduodenal ulcers with the use of local inhibitors of proteolysis, with contrykal among other drugs. Experimental ulcers have been induced in rats according to Okabe. Eighty-three patients have been treated with the suggested schemes. The activities of lysosomal proteinases have been studied both experimentally and clinically. Local injections of contrykal into the ulcer had inhibited proteinase activity and had a positive therapeutic effect.

Adolescent↗
PubMed1989

[Immediate results of the use of prospidin in a cyanoacrylate glue compound in cancer of the esophagus].

Antitumor efficacy of a medical adhesive MK-8-based polymer drug composition with prospidin has been studied in 49 Wistar rats, and the kinetics of the drug elimination has been followed up in 112 rats. The findings evidence a prolongation of a relapse-free period and a longer survival of the animals. Clinical trials of the composition have been carried out. Of the 70 patients with esophageal carcinomas 52 ones had local disseminated forms, conforming to T4P3-4 indices. Application of the adhesive composition has not increased the rate of postoperative complications and in some cases considerably prolonged the life span of patients after palliative surgery.

Animals↗
PubMed1989

[Results of the local endoscopic treatment of chemical burns of the esophagus using medical glues].

The results of treatment of chemical burns of the esophagus in 140 patients with the medical glues MK-8 and MK-14E. Application of the glues was undertaken in the presence or absence of hormone therapy. The method of glue application is described. The use of the method reduces the time of healing of the destructive lesions of the esophageal mucosa in chemical burns and facilitates the prevention of complications.

Adolescent↗
PubMed1988

[Pharmacokinetics of anthracycline antibiotics deposited by polymers].

An increase of doxorubicin concentration in different organs and tissues and its decrease in the peripheral blood were observed when studying pharmacokinetics of this drug administered in the 10% solution of polyvinylpyrrolidone. A prolonged and stable release of carminomycin from glue composition MK-10-0 "carminacryl" confirms an expediency of alpha-cyanoacrylate use for deposition of anthracycline antibiotics with the aim of loco-regional chemotherapy.

Animals↗
PubMed1979

[Stability and the biodestruction of polymer compositions for joining and replacing bone tissue].

Ethylcyanacryl-based compositions were subjected to gravimetric studies with the use of standard specimens in numerous laboratory tests and in 60 experiments on rabbits. Compositions with various fillers were studied. A relatively high elimination rate or orotic acid, microcapsulated in dextrane, from polymerized blocks was found. The results of the studies have shown the expediency of further improvement of the composition for the alignment and replacement of the bone tissue.

Animals↗