Biomedical subjects
Publications and source records attributed to A Ia Evtushenko.
The article covers results of studies in occupational hygiene and physiology, occupational traumatism, morbidity among coal miners of Kouzbass; evaluation of occupational morbidity risks and environmental state in coal miner towns.
Cardiac output and parameters of myocardial contractility in the post-resuscitation++ period of acute coronarogenic infarction were studied in experiments on dogs anesthetized with nembutal (40 mg/kg) (29 dogs). Twelve dogs reanimated after fibrillation-induced cardiac arrest were used as controls. The duration of clinical death was 5 minutes. The experimental animals showed a phase pattern of changes with initial hyperperfusion that was less pronounced in infarction and with subsequent one that was more profound than did the controls. A greater degree of +blood circulation disturbances were shown to be associated with high postresuscitation death rates. Diminished cardiac output is originally related to inhibited myocardial contractility; subsequently, of great importance are hypovolemia and arrhythmias.
The experiments were conducted on cats under pentobarbitone sodium anesthesia (40 mg/kg). The effect of 30-min hypovolemia (Wiggerse's model, 13.3 kPa or 100 mm Hg) on the cardiac output, its main fractions and the survival of animals recovered after clinical death (5 min) were studied. Hypovolemia was induced after cardiac contractions were recovered. In experimental (19 cats) and control (23 cats) studies clinical death was caused by arterial blood loss. The animals had been previously subject to hemorrhagic hypotension (according to Wiggerse, 6.7 kPa or 50 mm Hg, for 30 minutes). Temporary exclusion of part of blood volume from the circulation was found to abolish the phase of cardiac output increase in the postresuscitation period, attenuate the reaction of blood circulation centralization, improve the course of reparative processes and increase the survival of animals recovered after clinical death.
Experiments on cats were made to study the cardiac output and its main fractions supplying blood to the epi- and subdiaphragmal parts of the body during the postresuscitation period. The phenomenon of early postresuscitation centralization of circulation was established, correlating with the gravity of the sustained terminal state in the severity and duration.
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Experiments were conducted on nembutal-anesthetized cats; a study was made of the dynamic viscosity of the blood, and also of an aggregation capacity of the blood formed elements for two hours of the postresuscitative period. There was established an increase in the viscosity both in the zone of a low (1.82 dynes/cm2) and high (10.94 dynes/cm2) sear stress. A definite role in increase of the blood viscosity is played by a rise in the hematocrite index and by enhanced aggregation capacity of the blood formed elements.
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Clinical and prognostic significance of early postresuscitation changes in static and dynamic parameters of blood plasma lipid peroxidation (LPO) is studied in cats subjected to 5-min clinical death from blood loss after preliminary 30-min hemorrhagic hypotension. Assessment of dynamic parameters of LPO in addition to the static ones notably improved the reliability of prediction of the course of postresuscitation disease.
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It was demonstrated in experiments with cats, who survived a 5-minute clinical death caused by a prolongated blood loss, that the determination of lipid-peroxidation dynamic indices, made in incubated homogenates, reveals the altering ratios between the pro- and anti-oxidant activities as well as those ratios leveled by rapid shifts in hemodynamic parameters; it also displays the quantitative, qualitative and temporal differences of such ratios in the brain, liver and kidneys at dying and immediately after reanimation, which can not be detected by determining the content of lipid-peroxidation products in tissues in vivo.
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