Biomedical subjects

A Iacobovici

Publications and source records attributed to A Iacobovici.

22 records · Page 2Linked to original sources

PubMedDate not supplied

[The evaluation of a method for determining apolipoproteins as a sensitive indicator in assessing lipid metabolic disorder in a population at risk for essential arterial hypertension (EAHT)].

The increased efficiency of epidemiological screening tests in determining the prevalence of risk factors carriers required the use of highly sensitive markers able at detecting early, in reversible stages, the disturbances in the lipid metabolism genetically induced or acquired during lifetime, known as major risk factors for essential hypertension and other cardiovascular diseases. The authors report the preliminary results of some investigations on the predictive value of apolipoproteins. Immunokits manufactured by BioMérieux--France were used. In 50 admitted patients with essential hypertension and family history of risk, high levels of apoA1 and apoB were recorded although cholesterol and other biological markers were within the normal. At the same time, in our case the apoB/apoA ratio was supraunitary, fact proving the validity of the method.

Apolipoproteins↗

PubMedDate not supplied

[Multidisciplinary epidemiological observations on the role of mineral elements and other environmental factors in inducing essential arterial hypertension].

The results of a pluridisciplinary epidemiological study carried out on a series of 225 adults from rural areas, in whom the prevalence of arterial hypertension disease (AHTD) and borderline (AHTB) was of 19.0% and 14.4%, respectively, are presented. In 19.0% of the carriers of over five associated risk factors for cardiovascular disease, the classical lipid constants (triglycerides-TG. total lipids-TL. total cholesterol-TC. HDL-cholesterol-HDL-c), plasma (PML) and erythrocyte magnesium level (EML), as compared to the degree of drinking water mineralization were determined. The environmental conditions, also expressed in water hardness (21.650 G) or magnesium water intake (85.13 mg/l) correlate in 41.0% of the subjects with a decrease in PML (1.8 mg/l) and in 70.48 with a decrease in EML (4.8 mg/l) through the association of some behavioral or metabolic risk factors: stress, consumption of atherogenic foods, excess alcohol and lipid dysmetabolism (TG: 130-140 mg/l = 59.5%; TL: 8 g%-30.9%; TC: 220 mg/l = 19%; HDL-c: 35 mg/l + 1.9%).

Adult↗

PubMedDate not supplied

[The clinico-epidemiological premises for antioxidant prevention and treatment in chronic myocardial infarct].

The improvement of therapeutic and recoverable proceeding to chronic myocardial infarction (IMC) imposes a complex epidemiological estimation of the global cardiovascular risk, of their clinical and biological status. The retrospective evaluation of the risk factors (RF) by epidemiological methods, in 38 hospitalized prevalence of both constitutional and behavioral factors, and the quantification of the risk state, according to graph Euro 194, has pointed on the fact that 50% of IMC cases have presented a global risk of 10-20%. That justified the application of a preventive conduct in order to continually neutralize the associates FR. The biochemical determinations have allowed to frame the dyslipidemic patients, according to the ARCOL classification in the classes D (29.2%), E (25.0%) and B (20.8%) with direct implication in the adopted therapy. The colorimetric dozing with thyo-barbituric acid of the malonly dialdehyde (MAD) each is a product of the lipidic peroxidation, as well as the interpreting or correlation of the registered values with an evolutive clinic stage, and with the existence of some existing diseases (diabetes, chronic hepatitis etc.) along with signification of other dismethabolical parameters (cholesterol, triglycerides, LDLc, apoB) have confirmed the necessity of a complex therapy, including an antioxidative treatment, having the role to directly inhibit or exclude the free radicals resulted after the oxidative stress of the infarct.

Antioxidants↗

PubMedDate not supplied

[The lipid peroxidation process in depression: the effect of trazodone].

We investigated the lipid peroxidation in depression by determining the markers of this process: melondialdehide, total SH groups and catalase. We used blood samples from inpatients with specific psychiatric symptoms. The medication consist of hypnotic nitrazepam and antidepressant trazodone, using film-coated tablets trazolon, 50 mg once a day, three weeks. In the second part of our experiment, we studied the antioxidant properties of trazodone, using blood samples from healthy subjects. It remain to establish if the free radicals are responsible for the initiation of depression or not.

Adult↗