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Biomedical subjects

A Ibarra Peláez

Publications and source records attributed to A Ibarra Peláez.

8 recordsLinked to original sources

[Small cell anaplastic carcinoma of the colon].

Small-cell anaplastic carcinoma of the colon is a very infrequent tumour (less than 1% of all colorectal neoplasms). Thirty-two cases have been described in the international literature up to 1992. A case, in a 54 year-old patient who underwent successful resection is presented. The importance of this tumour is due to its great aggressivity, and its great tendency to produce early hematogenous and lymph node metastases. It implies a bad prognosis and a survival of around 0% at one year. Because of these facts, treatment must include, beside surgical resection, an aggressive systemic protocol.

Carcinoma, Small Cell↗

[Hepatic adenoma and focal nodular hyperplasia: difficult differential diagnosis. Presentation of a case of focal nodular hyperplasia].

Hepatic adenoma and focal nodular hyperplasia are unfrequent benign lesions of the liver with individual histologic characteristics, but not always clinically distinguishable. The main difference is the intratumoral or intraperitoneal bleeding risk (high in adenoma and virtually zero in focal nodular hyperplasia). Surgery is the elective treatment for the first, while a more conservative attitude is allowed for the second. We present the case of a woman with an hepatic mass that clinically and radiologically seemed to be an adenoma. An atypical hepatectomy was done uneventfully. The examination of the specimen showed shaw focal nodular hyperplasia. We review the diagnostic and therapeutic controversy between these entities, because only the histologic examination of the entire surgical specimen could demonstrate the real nature of the lesion.

Adenoma↗

[Significance of flumazenil in acute benzodiazepine poisoning].

Thirty-five patients over 14 years of age were evaluated, with the common feature of benzodiazepine poisoning, either as a single drug or associated with others and/or with ethanol, and who had a Glasgow score lower than 10 at admission. These patients were treated with flumazenil as a competitive antagonist drug. The results were very satisfactory. Subsequently, the possible relationship between the effect of flumazenil and the pharmacokinetic benzodiazepine profile was evaluated, and a significant relationship between the half life and the degree of resedation of the patients was found.

Acute Disease↗

[Epidemiological approach to acute poisoning in Asturias].

Two hundred and twenty cases of acute overdoses are revised using a specific protocol. We have found a larger number of cases of overdoses to exist in women (62.73%), at an average of 32 years of age, the typical deviation being that of 15.8. Intentional overdoses are predominant (80%), 55.1% using benzodiazepines. The abuse of one sole drug (67.3%) is greater in comparison to combining drugs sole drug (67.3%) is greater in comparison to combining drugs with alcohol (10.2%). The treatment most often used was stomach pumping (49.5%), being effective in 76.1% of the cases Hospitalizations total 16.8%, with 30% remaining in observation. A comparison of our study is made with available Spanish sources, demonstrating: a) The smaller number of acute overdoses. b) The increasing importance of the acute overdoses caused by benzodiazepines and derivatives of opium, thus the interest in the use of antidotes such as Naloxone and Flumazenil which improve the prognosis of these patients. In our series in particular, there is a 0% death rate.

Acute Disease↗