[An autopsy case of hepatocellular carcinoma producing human chorionic gonadotropin (hCG)].
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Aged↗
Biomedical subjects
A Ichinoe
Publications and source records attributed to A Ichinoe.
[Clinical studies on preoperative abdominal arterial infusion of anticancer agents].
Operable patients with gastrointestinal cancer were injected once with MMC 0.4 mg/kg, ADM 0.8 mg/kg or KW 2083 1 mg/kg through the abdominal artery 7 to 15 days before operation. Biopsy was made on liver tissues during operation, and changes of serum biochemical test values were observed before and after operation. In 7 cases of MMC 20 mg arterial infusion, 7 cases of ADM 40 mg and 6 cases of KW 2083 50 mg liver biopsy showed fibrosis around the central vein. Eosin bodies, neutrophils or necrotic lesions were observed in some other cases. Serum biochemical test values were transiently affected with anesthesia, but these changes will have no unfavorable influence on the results of operation and following treatment.
Abdomen↗
Nonalcoholic steatohepatitis and cirrhosis with Mallory's hyalin with ultrastructural study of one case.
Clinical features and liver biopsy findings were studied in six patients with nonalcoholic steatohepatitis associated with hyalin. A comparative study was made on the ultrastructure of the hyalin in one patient with nonalcoholic steatohepatitis and in one patient with alcoholic hepatitis. The patients, all over 50 years old, comprised two females and one male with steatohepatitis and three females with micronodular cirrhosis. They showed obesity, hepatomegaly, and mild abnormalities on laboratory tests. Three of them showed maturity-onset diabetes. The hyalin was found in the cytoplasm of swollen hepatocytes of the centrilobular or in the peripheral region of nodules and was accompanied by necrosis. Ultrastructurally, the hyalin comprised filamentous structures and vesicular or angular structures resembling disorganized circular or branched rough endoplasmic reticulum. It resembled that found in the liver of patients with alcoholic hepatitis.
Fatty Liver↗
Sodium valproate-induced liver injury.
Centrilobular zonal necrosis developed in the liver of a 37-yr-old woman who had been taking sodium valproate for 1 month as prophylactic anticonvulsant medication after a cranioplasty. A challenge test was positive. Ultrastructurally, the hepatocytes revealed megamitochondria with crystalline inclusions, disorganized rough endoplasmic reticulum, and no increase in smooth endoplasmic reticulum. These findings suggest that cytotoxic liver injury was induced by sodium valproate in our patient.
Adult↗
Viral hepatic diseases and microsomal arylamidase activity in liver tissue.
The relationship between microsomal arylamidase activity, determined by a micromethod, and changes of hepatocytes was studied in biopsy samples taken from 107 patients with normal liver histology and viral hepatic diseases. The activities in healthy carriers and chronic persistent hepatitis patients were significantly greater than those of controls, acute hepatitis and chronic active hepatitis patients, and showed a significant greater than those of controls, acute hepatitis and chronic active hepatitis patients, and showed a significant correlation to morphologic criteria. Ultrastructurally, regularly increased smooth endoplasmic reticulum (SER) was found especially in healthy carriers. The arylamidase activity reflects virus-induced changes of the SER in healthy carriers and viral hepatic diseases.
Aminopeptidases↗
Hydralazine-induced hepatitis.
Three patients developed hepatic injury two months, ten months and two years, respectively, after hydralazine therapy for hypertension. Clinical and biochemical recovery followed discontinuation of drug therapy. Liver biopsies of the three patients revealed varying degrees of centrilobular necrosis. Complement 3 and Complement 4 levels were measured and found to be low in the patient with poor liver synthetic function, as was evident from the low serum albumin level and prolonged prothrombin time. Hydralazine-induced liver injury may be due to abnormality of drug metabolism in the liver.
Chemical and Drug Induced Liver Injury↗
Hydralazine-induced liver injury.
A 68-year-old man developed hepatic injury with no hypersensitivity reaction after three years of hydralazine therapy. The liver injury histologically showed centrilobular zonal necrosis. Clinical, biochemical, and histological recovery followed discontinuation of the drug. Challenge tests and serial liver biopsies revealed that this liver injury was induced by hydralazine.
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Drug-induced liver injury and microsomal arylamidase activity in needle biopsy of human liver.
The relation between the activities of arylamidase (one of the non-specific carboxylesterases) located exclusively in smooth endoplasmic reticulum (SER), and microscopical changes of the hepatocytes, was studied in three patients treated with phenobarbital and twenty-five patients injured by various other drugs. A micro-method was used for the determination of the enzyme activity in small pieces of liver (5-15 mg) obtained by needle biopsy. The arylamidase activity in seven normal livers was 0.43 +/- 0.05 (SD) nmol benzylhydrazine/micron protein/hr formed from isocarboxazid. The mean value in the livers treated with phenobarbital was statistically different from the value before phenobarbital treatment (P less than 0.05). Of sixteen cytotoxic type samples, seven showed low activity and eight high activity, respectively. Of the seven mixed-type samples, three showed mildly low activity and four normal activity. The frequency of the cytotoxic type is statistically different from that of the cholestatic (mixed and pure cholestatic) type comparing the abnormal activity with normal activity (P less than 0.05). The degree of enzyme activity was related to changes such as pyknosis, enlarged nuclei and centrilobular zonal necrosis. The ultrastructure of the material taken from three patients after phenobarbital treatment and one patient with ibuprofen-induced injury showed prominent increase and vesiculation of SER respectively. The study shows that drug-induced liver injury is closely related to the activity of SER, and that the changes in hepatocytes in cytotoxic type may result from the functional abnormality of SER.
Adult↗
Five patients with nonalcoholic diabetic cirrhosis.
Five nonalcoholic diabetic women were clinically and histologically verified as having micronodular cirrhosis. In this series all the patients were over 50 years of age, and showed obesity, hyperglycemia, enlarged liver and mild abnormalities of liver function tests. The histological findings differed from hepatitic cirrhosis. In two patients serial biopsies confirmed development of cirrhosis from centrilobular necrosis.
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Nonalcoholic fatty liver with alcoholic hyalin after long-term glucocorticoid therapy.
Alcoholic hyalin was found in liver of a nonalcoholic patient with fatty liver after long-term glucocorticoid therapy for systemic lupus erythematosus. Hepatocytes including hyalin bodies showed fatty change or vesiculated degeneration. Occasionally, basophilic substance which was recognized in the hepatocytes with or without hyalin was noticed showing the feature quite similar to delicate alcoholic hyalin.
Adult↗