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Biomedical subjects

A Iellin

Publications and source records attributed to A Iellin.

18 recordsLinked to original sources

Association of von Willebrand's disease with plasma cell dyscrasia and gastrointestinal angiodysplasia.

A patient with acquired von Willebrand's disease (type I) had both plasma cell dyscrasia and angiodysplasia of the intestine. Based on examination of the components of F VIII/von Willebrand's factor (VWF) and the results obtained following the administration of cryoprecipitate and DDAVP (1-desamino-8-D-arginine-vasopressin), it was suggested that the production and release of VIII/VWF was normal and the rapid disappearance from the circulation was related to adsorption by abnormal cells in the bone marrow. The relation of acquired von Willebrand's disease, plasma cell dyscrasia and angiodysplasia is discussed and the literature reviewed. Our patient is added to three previous reported cases of such an association of these three disorders.

Blood Vessels↗

Recurrent bladder perforation in chronic irradiation cystitis.

Chronic irradiation cystitis may cause fibrosis and weakening of the detrusor, with greater susceptibility of the bladder wall to endoscopic trauma. We lately treated a patient with chronic irradiation cystitis who sustained recurrent bladder perforation, one after electrohydraulic lithotripsy and the other--following cystoscopy. The first event was handled surgically and the second one in a conservative approach. We hereby report on the case and comment on the etiology.

Aged↗

Thromboendarterectomy combined with femoropopliteal bypass.

Most complications that appear within 5-6 weeks after femoropopliteal bypass (FPB) are associated with the surgical procedure in the groin. Destruction of lymphatic structures in the presence of an open foot infection and crushing of the intima by clamping the common and deep femoral arteries are significant predisposing factors in producing early infection or occlusion of the graft. To avoid these predisposing factors, a combined procedure of a short thromboendarterectomy of the proximal superficial femoral artery and an autogenous or prosthetic bypass graft was used, without application of clamps to the common and deep femora arteris. In a series of 45 patients, this combined procedure was used and a significant reduction of complications was achieved. Indications, technique, and advantages of this combined method are discussed.

Bacterial Infections↗

Acute myocardial infarction and arterial embolectomy.

Emboli of a main artery cause serious complications in patients suffering from acute myocardial infarction, in whom the surgical risk is high. In order to save the limb, embolectomy is indicated and should be considered. Early diagnosis and prompt surgical intervention with the use of the Fogarty catheter simplify the embolectomy procedure and enable restoration of circulation to the ischaemic limb. Thirty-two embolectomies were performed in twenty-eight patients suffering from acute myocardial infarction. Patients with cardiac compensation survived the surgery and recovered. However 50% of the patients in whom acute myocardial infarction was accompanied with congestive heart failure and arrhythmias died. The cause of death was the underlying disease. Considering the severity of the acute myocardial infarction this group of patients represents the expected mortality.

Aged↗

Midgut volvulus with secondary thrombosis of superior mesenteric vessels in a pregnant woman.

An anomaly of the position of the midgut in a pregnant woman predisposes to volvulus. Vascular repair, despite the abdominal catastrophe, sometimes allows parts of the intestine to be saved. A case of volvulus in a pregnant woman is described. At operation, 18 hours after onset, two anomalies were found: reverse rotation of the midgut and an anomaly of the collecting system of the superior mesenteric vein. Most of the midgut was infarcted. Thrombi were removed from the superior mesenteric vessels, and a portion of the anamalous superior mesenteric vein was reconstructed. All but 3 M. of the small bowel and the entire right colon were resected. Prolonged treatment with parenteral hyperalimentation enabled us to control the appearance of a moderate degree of malabsorption. To our knowledge, no similar case has been reported previously in the literature.

Adult↗

Candida sepsis successfully treated by parenteral administration of 5-fluorocytosine.

Candida sepsis has become one of the most common and dangerous forms of hospital acquired infection. The recommended drug for parenteral treatment of Candida sepsis is amphotericin B, however, its toxic effects preclude its usage in many patients, particularly in the presence of renal failure. A less toxic antifungal agent is 5-fluorocytosine. A patient with Candida albicans sepsis was treated successfully with 5-fluorocytosine by intravenous administration. The fungal infection developed during the course of acute renal failure, repeated surgical intervention, intravenous hyperalimentation, gastrointestinal bleeding and five months of antibiotic therapy. The clinical symptoms receded rapidly and cultures became sterile after one week of intravenous treatment. The predisposing factors, difficulties in prevention and diagnosis of fungal infection are discussed.

Adult↗

Acute ischemia of the limb in a newborn treated successfully by thrombectomy.

A seven day old dehydrated male infant was found to have acute ischemia of the leg due to acute thrombotic occlusion of an external iliac, common and superficial femoral, and popliteal arteries. Early thrombectomy and arterioplasty resulted in complete remission of ischemia. Our success with direct vascular surgery prompts us to recommend this form of treatment in preventing neonatal gangrene. To our knowledge, this is the first report of successful thrombectomy in a newborn infant.

Acute Disease↗

Spontaneous pneumoperitoneum without peritonitis.

Spontaneous pneumoperitoneum without peritonitis is a rare phenomenon which poses a dilemma to the surgeon faced with this problem. Two such cases and their outcome are presented. The first case was caused by barotrauma during positive pressure ventilation and was treated by laparotomy. No perforated viscus was found. The second case was caused by tracheal rupture during emergency intubation and was treated by observation until complete resolution. Both patients died for reasons unrelated to the pneumoperitoneum. The mechanisms for passage of air from the chest into the abdominal cavity were through the diaphragm in the first case and along the great vessels in the second. A compilation of other etiologies of pneumoperitoneum without peritonitis as extracted from the literature is presented. In the presence of pneumoperitoneum without peritonitis and when the clinical history does not suggest perforation of a viscus, we advise performing an abdominal tap. If negative, continued observation is advised.

Aged↗

Malignant fibrous histiocytoma of the breast.

Primary Malignant Fibrous Histiocytoma (M.F.H.) of the breast proper is a very rare tumour. From the limited number of cases reported so far (22 including the present one), it seems that a rather high rate of local recurrence and lung metastasis might be expected, and that there is still uncertainty as to the most adequate treatment of the tumour. Therefore, the need for regional node dissection appears justified and we describe herein a case treated by breast quadrantectomy and axillary lymph node dissection.

Breast Neoplasms↗

Rupture of a hydatid cyst of the liver into the biliary tract.

Rupture of a hydatid cyst into the biliary tract occurs in 5% to 10% of patients with hydatid disease of the liver. The communication between the hydatid cyst cavity and the biliary tree may produce intermittent or progressive obstructive jaundice. The presence of such jaundice complicates the diagnosis since it resembles other biliary disorders such as stone or infection. We treated six patients with hepatic hydatid cysts, four with minute fissures and two with wide ruptures into the biliary tract. The pathophysiologic mechanisms, diagnostic procedures and treatment are discussed.

Adult↗