On the role of the elastic properties of closed lamellar membranes in membrane fusion.
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Animals↗
Biomedical subjects
A Iglic
Publications and source records attributed to A Iglic.
The required resultant abductor force and the available resultant abductor force after operative changes in hip geometry.
The required abductor force (Freq) and the available abductor force (Fav) are calculated for different positions of the hip rotation center (RC) and different greater trochanter (GT) shifts in the frontal plane of the body in the one-legged stance. It is biomechanically favorable that Fav exceeds Freq and that the magnitude of the resultant hip joint force (R) after the operation is decreased. The difference between Fav and Freq, which represents the relative abductor strength, increases after medialization of RC and after lateralization of GT. On the contrary, after medialization of GT and after lateralization of RC, the difference decreases, which has unfavorable biomechanical effects. Distalization of GT is favorable because it increases the relative abductor strength.
Biomechanical Phenomena↗
Resultant hip joint force after total hip replacement.
Bending moments acting on the LIMA-LTO femoral stem were calculated using a 3D mathematical model of the hip in the one-legged stance based on muscle anatomical data. The effects of 1 cm medialization and lateralization of the hip joint rotation centre (RC) on the bending moments were determined for different body weights. It was found that the bending moments and hence the stem loosening incidence are higher in lateralization compared to medialization of the RC. In order to diminish the bending moments, body weight should be reduced.
Biomechanical Phenomena↗
Biomechanical analysis of various operative hip joint rotation center shifts.
A mathematical model was used to evaluate the mechanical situation after various operative shifts of the hip joint rotation center. It was concluded that while performing different pelvic osteotomies and the total hip replacement the hip joint rotation center should be shifted as far medially as is technically possible to reduce the magnitude of the hip joint contact force. By contrast, lateralization of the hip joint rotation center strongly increases the magnitude of the hip joint contact force; therefore this should be avoided whenever possible. The superior shift of the hip joint rotation center decreases the strength of the patient's hip abductor muscles and must therefore also be avoided. The inferior shift of the hip joint rotation center is favorable because it increases the strength of the patient's hip abductor muscles.
Adult↗
Computer simulation of periacetabular osteotomy.
A simple static three-dimensional mathematical model of an adult hip in one-legged stance was used to evaluate the mechanical situation after periacetabular osteotomy. We found that the hip joint rotation center shifted as a consequence of the osteotomy. This may have considerable effects on the hip joint resultant force and therefore also on the pressure on the femoral head, which could cause the development of arthrosis.
Acetabulum↗
Amphiphile-induced vesiculation in aged hereditary spherocytosis erythrocytes indicates normal membrane stability properties under non-starving conditions.
Aged HS erythrocytes with a defined primary defect in band 3 protein or ankyrin were incubated with amphiphiles (detergents) at sublytic concentrations (37 C, 60 min) or glucose-starved (37 C, 24 h). In line with previous studies, the release of AChE (exovesicles) from HS erythrocytes during glucose-starvation was significantly higher (11%) compared to that from control erythrocytes (1%). Control and HS cells responded, however, similarly to amphiphile-treatment (non-starving conditions). Amphiphiles induced similar types of shape alterations and a similar amount of AChE release (14-15%). Furthermore, the size and shape of amphiphile-induced exo- and endovesicles released from control and HS erythrocytes were similar. The results suggest that the stability properties of the membrane are not seriously disturbed in aged HS erythrocytes under non-starving conditions.
Antiporters↗