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Biomedical subjects

A Inaba

Publications and source records attributed to A Inaba.

54 records · Page 3Linked to original sources
PubMed1990

[Interspecific hybridization in the Drosophila takahashii subspecies complex].

To elucidate the relationship between 6 species involved in the Drosophila takahashii complex, we analyzed the existence of interspecific hybridization, hybrids number with sex ratio, and the reproductive status of the hybrids of these species. We found that each of the 6 species formed hybrids with at least one other species. The most closed relationship among these species was confirmed to be between D. lutescens and D. trilutea, and D. prostipennis was rather isolated from the other 5 species. In ascending order D. takahashii showed a closed relation to D. lutescens, D. trilutea, and D. paralutea. It was shown that D. prostipennis and D. nepalensis form hybrids with D. paralutea and D. lutescens, respectively.

Animals↗
PubMed1989

[Clinical study of bruxism. Comparison of muscle activity during sleep between patients conscious of bruxism and those not conscious of the condition].

Bruxism has been considered to be one of the most important factors in accelerating the progression of established periodontal lesions. However the objective diagnostic method has not yet been established. At present, diagnosing bruxism might mainly be dependent on interview. The purpose of this study was to compare and analyze the differences in frequency and duration of bruxism between a group of patients conscious of the problem and a group not conscious of bruxism. After interviewing, the subjects were divided into two groups; 1) group A consisted of 8 subjects who were conscious of bruxism and 2) group B of 8 subjects who were not conscious of bruxism. The frequencies and durations of muscle activity during sleep at night were compared between groups A and B using EMG with a telemetric method. In the one-night observation, muscle activity supposed to be bruxism was observed in both groups. Significant differences in frequencies of muscle activity were not found between the two groups. A similar result was obtained in the durations of muscle activity. In a seven-day observation, muscle activity was seen in all three volunteers, although marked differences were not found among them. A long duration of muscle activity was found under conditions of physical or mental stress. The results of this study showed the difficulty of diagnosing bruxism by interview and the necessity of an objective method.

Bruxism↗
PubMed1987

Inhibition of alkaline phosphatase activity and D-glucose uptake in rat renal brush-border membrane vesicles by aminoglycosides.

The binding of aminoglycoside antibiotics to, and their effects on, the plasma membrane were studied using isolated rat renal brush-border membrane vesicles. Dibekacin was noted to bind with brush-border membrane vesicles having a single class of many binding sites. 3H-labeled dibekacin binding was inhibited competitively by unlabeled dibekacin, gentamicin or amikacin. The inhibition constants obtained from the Dixon plots followed the order of gentamicin approximately equal to dibekacin greater than amikacin. The alkaline phosphatase activity of brush-border membrane vesicles was inhibited by gentamicin significantly, as was also observed by a histochemical study. Sodium-dependent D-glucose uptake by brush-border membrane vesicles was significantly inhibited by the addition of gentamicin.

Alkaline Phosphatase↗
PubMed1986

Uptake of aminoglycoside antibiotics into brush-border membrane vesicles and inhibition of (Na+ + K+)-ATPase activity of basolateral membrane.

The effects of aminoglycoside antibiotics on plasma membranes were studied using rat renal basolateral and brush-border membrane vesicles. 3',4'-Dideoxykanamycin was bound to the basolateral membrane and brush-border membrane vesicles. They had a single class of binding sites with nearly the same constant, and the basolateral membrane vesicles had more binding sites than those of the brush-border membrane. Dideoxykanamycin B was transported into the intravesicular space of brush-border membrane vesicles, but not into that of basolateral membrane vesicles. The (Na+ + K+)-ATPase activity of the plasma membrane fraction prepared from the kidney of rat administered with dideoxykanamycin B intravenously decreased significantly. Aminoglycoside antibiotics entrapped in the basolateral membrane vesicles inhibited (Na+ + K+)-ATPase activity, but those added to the basolateral membrane vesicles externally failed to do so. The activity of (Na+ + K+)-ATPase was non-competitively inhibited by gentamicin. It is thus concluded that aminoglycoside antibiotics are taken up into the renal proximal tubular cells across the brush-border membrane and inhibit the (Na+ + K+)-ATPase activity of basolateral membrane. This inhibition may possibly disrupt the balance of cellular electrolytes, leading to a cellular dysfunction, and consequently to the development of aminoglycoside antibiotics' nephrotoxicity.

Aminoglycosides↗
PubMed1986

Binding of 3',4'-dideoxykanamycin B to ATP and its related compounds.

The interactions of aminoglycoside, 3',4'-dideoxykanamycin B(DKB) with ATP and its related compounds were investigated. ATP, ADP, cyclic AMP and FAD bound to the DKB-conjugated Sepharose 4B column. The binding of DKB to ATP was also confirmed by equilibrium gel filtration. In the acidic pH region, the fluorescence of nucleotides was quenched by DKB. The Stern-Volmer plots showed that the molar ratios of the complexes were 1:1. The apparent stability constant was dependent on the number of the phosphate groups of nucleotides and was in the order of ATP greater than ADP greater than AMP.

Adenosine↗
PubMedDate not supplied

Selective incorporation of asialofetuin into hepatocyte of rat.

The disposition of asialofetuin was studied in the rat. The radioactivity of 3H-asialofetuin administered intravenously disappeared rapidly from the blood. Asialofetuin was specifically and rapidly incorporated into the liver, and had no affinity toward other tissues such as the lung, spleen, heart, and kidney. Asialofetuin accumulated in the lysosomal and microsomal fractions of the rat liver cells immediately after administration, shifted to the low dense fraction (cytosol fraction) with the elapsing of time, and was possibly digested by lysosomes. The elimination of 3H-asialofetuin from the liver was fast and the degradates excreted into the bile and urine represented 90 per cent of the dose administered by 180 min following administration. It was suggested that asialofetuin functions as a carrier of drugs to the liver, especially to hepatocytes.

Animals↗
PubMedDate not supplied

Hawaiian-style "talkstory": psychosocial assessment and intervention during and after pregnancy.

Standard health care services generally limit the psychosocial assessment and management provided for women during and after pregnancy. Recommendations for improving prenatal care include the need for evaluating different approaches for addressing culturally sensitive care. In an innovative prenatal and postpartum program developed by public health nurses in Hawaii, the use of local "talkstory" has been integrated successfully as a caregiving strategy for participating women from Asian and Pacific Islander ethnic groups. This article describes the use of talkstory for delivering psychosocial care and its application in the design of health care services for pregnant women in the general population.

Asian↗
PubMedDate not supplied

Role of prostaglandin E2 in rat colon carcinoma.

BACKGROUND/AIMS: It has previously been reported that prostaglandin E2 (PGE2) promotes colon carcinogenesis. We therefore studied the effects of long-term administration of prostaglandin E2 (PGE2) on colon carcinogenesis in rats. METHODOLOGY: Rats received intrarectal n-methyl-n-nitrosourea (MNU) or n-methyl-n-nitrosoguanidine (MNNG) to induce the formation of colonic tumors. Rates then received indomethacin (IND) and/or PGE2, or nothing. After 44 weeks (MNU group) or 46 weeks (MNNG group), colon lesions were identified histologically and colonic mucosa PGE2 concentrations were measured by radioimmunoassay. RESULTS: The incidence of colon carcinoma in the control, MNU, MNU + IND, MNU + PGE2, and MNU + IND + PGE2 groups was 0/14, 5/15, 0/14, 4/10, and 2/9, respectively. In the MNNG group, no tumors were observed. Induction of colon carcinomas by MNU was completely inhibited by IND, while exogenous PGE2 blocked the inhibitory effect of IND. However, PGE2 administration did not accelerate colon carcinogenesis. Neither MNU nor MNNG alone resulted in increased colonic mucosal PGE2 concentrations, whereas exogenous PGE2 administration significantly increased mucosal PGE2 concentrations. IND significantly decreased the mucosal concentration of PEG2 with or without PGE2 administration. CONCLUSIONS: These results suggest that endogenous PGE2 in colon mucosa may be adequate to promote colon carcinoma. To block colon carcinogenesis, PGE2 levels in colonic mucosa must be decreased to less than endogenous levels.

Animals↗