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Biomedical subjects

A Inbal

Publications and source records attributed to A Inbal.

62 records · Page 4Linked to original sources
PubMed1985

A therapeutic trial with low-dose cytarabine in myelodysplastic syndromes and acute leukemia.

The myelodysplastic syndromes are a group of bone marrow stem cell disorders which were considered refractory to chemotherapy until recently. Low-dose cytarabine was given to 6 patients with symptomatic myelodysplastic syndromes and 2 patients with acute leukemia. 5 patients responded to therapy, 3 of whom with refractory anemia achieved normalization of peripheral blood counts. Therapy was well tolerated, myelosuppression was the predominant side effect. This preliminary trial demonstrates that patients with symptomatic myelodysplastic syndromes, particularly patients with refractory anemia may be benefited by low-dose cytarabine therapy.

Acute Disease↗
PubMed1985

High-output cardiac failure as a presenting symptom of plasma cell leukemia.

A patient presented with high-output cardiac failure and was found to have plasma-cell leukemia. No cause for the cardiac failure was found, and there was no response to treatment with diuretics and thiamine. Chemotherapy for the leukemia resulted in resolution of the cardiac failure, suggesting that the latter was caused by the leukemia--a hitherto unreported association.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1984

Interaction of spectrin with hemin disaggregates spectrin associations.

Crude spectrin preparations were extracted from red cell membranes either in dimeric or tetrameric forms and incubated at 4 degrees C with hemin. The mixtures were subjected immediately or after 18 hours to nondenaturing electrophoresis. It was found that immediately after addition of 0.3 mM hemin, the fraction of spectrin complexed with other skeletal proteins, disaggregated to tetramer and dimer forms. After incubation for 18 hours at 4 degrees C most of the spectrin appeared in two additional bands which contained more hemin and migrated on the gels as molecular weight forms smaller than the dimers. Since SDS electrophoresis showed that spectrin subunits retained their integrity in these mixtures, it was concluded that hemin bound spectrin dissociates with time into monomers. It is suggested that there are pathophysiological implications to the disaggregation of spectrin complexes in the cytoskeleton by hemin.

Erythrocyte Membrane↗
PubMed1983

Cyclic leukocytosis and long survival in chronic myeloid leukemia.

A patient with an unusually prolonged course of Ph' positive chronic myeloid leukemia is presented. His disease was marked by cyclic leukocytosis, various chromosomal aberrations and secondary thrombasthenia. In vitro culture studies and granulocyte-macrophage colony stimulating factor (GM-CSF) production were consistent with responsiveness of the leukemic clone to GM-CSF. The possible relationship between the long survival and the feedback regulation of leukopoiesis is raised.

Blood Platelets↗
PubMed1982

Recurrent venous thrombosis: the sole manifestation of an occult myeloproliferative disease.

A myeloproliferative disorder manifested by thrombocytosis, a high leukocyte alkaline phosphatase (LAP) score and an increased red blood cell mass was found in a 64-yr-old woman. During the previous 15 yr, recurrent venous occlusions had taken place, necessitating the resection of ischemic bowel segments and leading to extrahepatic portal venous obstruction. Numerous blood counts obtained during repeated hospitalizations were normal, and these thrombotic events remained unexplained. The sequence of events strongly suggests that the myeloproliferative disorder existed in an occult form during these years and was responsible for the venous occlusions. The possibility of a "smoldering" myeloproliferative disorder should be considered in patients with otherwise inexplicable thrombotic phenomena.

Female↗
PubMed1981

The watery diarrhea syndrome with hypercalcemia--a symptomatic response to phosphate buffer.

Two patients with the watery diarrhea, hypokalemia, achlorhydria syndrome are described. Both had hypercalcemia, hypophosphatemia and suppressed parathyroid hormone activity. On repeated occasions the diarrhea was controlled by oral or intravenous phosphate buffer. An exhaustive search by sophisticated non-invasive methods and by celiac arteriography failed to demonstrate a pancreatic tumor. Yet, in both cases fairly large pancreatic non-beta-cell adenomas were found at laparotomy. The removal of these tumors was followed by complete recovery.

Adenoma↗
PubMed1978

A retrospective study of patients with chronic myeloid leukemia diagnosed and treated at the Chaim Sheba Medical Center during the years 1966-76.

Forty patients with chronic myeloid leukemia diagnosed and treated at the Chaim Sheba Medical Center, Tel-Hashomer, during the period 1966-76 were reviewed. All the patients were treated initially with busulfan (MYLERAN). Asymptomatic patients or those whose blood counts were stable and remained below 50,000/microliter were not treated. Maintenance therapy was not prescribed as a routine. The median survival time of all the patients was over 60 months--longer than reported in the literature. Prognostic parameters for longer survival were found to be Hb level greater than 10 g/dl at the time of diagnosis (P = 0.04) and duration of first remission in the chronic stage more than six months (P = 0.03). A borderline trend for better survival was found in patients with initial platelet counts above 100,000/microliter (P = 0.07).

Busulfan↗