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Biomedical subjects

A Iu Kholodov

Publications and source records attributed to A Iu Kholodov.

4 recordsLinked to original sources
PubMed1989

[Lipoxin B, an enhancing factor of spontaneous platelet aggregation in whole blood].

The arachidonic acid metabolites, lipoxin B (5,14,15-trihydroxy-6,8,10,12-eicosatetraenoate) and 5,15-dihydroxy-eicosatetraenoate were shown to possess a marked effect on platelet aggregation and procoagulant activity. Lipoxin B increases and 5,15-dihydroxy-eicosatetraenoate decreases spontaneous platelet aggregation and procoagulant activity when added at various concentrations. The drugs tested were found to have no direct action on blood coagulation.

Animals↗
PubMed1989

[The reaction to heparin in patients with burn toxemia during extracorporeal detoxification].

The comparison of sensitivity to heparin before hemosorption in burn patients with high level of the blood middle molecular peptides before the operation on the heart in patients with rheumatic cardiac defect without changes in the blood peptide level was carried out. In the model experiments, the influence of a fraction of the middle molecular peptides obtained from the blood of healthy and burned dogs on the effects of heparin and protamine sulfate, and as well on thrombocytic aggregation was studied. The role of the middle molecular peptides in the alteration of response to heparin in burn disease is discussed.

Blood Coagulation↗
PubMedDate not supplied

[Effect of alpha1-acid glycoprotein on rheologic blood parameters in experimental thermal burns].

Experiments were conducted on albino noninbred mice and rats to study the effect of alpha 1-acid glycoprotein (alpha 1-AG) on burn healing. Injection of alpha 1-AG in the first 24 hours after the burn causes rapid epithelialization and increases contracture of the burn wounds. At the same time it increases the deformity of the red cells, reduces their hemolysis due to a mechanical effect, and reduces spontaneous aggregation of blood platelets. No authentic effect of alpha 1-AG on the aggregation of red cells was revealed. It is suggested that alpha 1-AG is a natural defence factor of the organism which prevents the development of microvascular thrombosis and limits in this way the size of the inflammatory and necrotic processes.

Animals↗