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Biomedical subjects

A J Cilliers

Publications and source records attributed to A J Cilliers.

7 recordsLinked to original sources

[Experiences of mothers of young hyperactive children].

An exploratory contextual study was undertaken to expand the insight into and the meaning of the perceptions of the mother of a hyperactive child. The phenomenological method of interviewing was used to gather data. The interviews were recorded on tape and later transcribed verbatim. The random test population consisted of eight participants who were specially selected for the purpose of this study. Data was analysed by way of content analysis. The results firstly crystallised in the mother's experiences with her hyperactive child and secondly in the elements which influenced these experiences. The mother's experience is contained in her involvement with her child and in her interaction with him. She experiences vehement feelings of anger, empathy, insufficiency, guilt and depression. At the same time there is the perception that she is responsible for her child's hyperactivity and the accompanying behavioural problems. The mother finds herself in a stressful situation where she is a buffer between her child and the world. Her experience is influenced inter alia by her religious system, personal stress, the behaviour of the hyperactive child, and the availability of support systems. Based on the findings of this study, it seems that the mother of young hyperactive children are already mentally ill to a degree, or are at risk to develop mental illness. In the light of this, group therapy seems to be the most meaningful intervention to support mothers of young hyperactive children.

Adult↗

Evaluation of the effect of atenolol on the reaction time of healthy volunteers.

The effect of atenolol on visual reaction time was tested in 30 healthy subjects in a between-subject double-blind placebo-controlled trial. Visual reaction time was defined as the time between the display of a light signal and its extinction by the subject. Acute or chronic administration of atenolol had no effect on visual reaction time when compared with placebo.

Adult↗

The natural history of the Q wave in inferoposterior myocardial infarction.

One hundred and twenty-five patients who had suffered transmural inferior myocardial infarctions were followed up for a mean period of 55 months. On electrocardiography the area under the pathological Q waves in the inferior leads was measured serially. Eighty-one patients (65%) showed a highly significant time-related diminution in Q-wave area. The ECGs of 17 subjects (14%) became normal and there was no electrocardiographic evidence of the previous myocardial infarction. The Q waves of the remaining 44 subjects (35%) remained constant or increased. A discussion of the possible mechanisms of changes in Q-wave size follows.

Adult↗

Correlation of ventricular ectopic activity and exercise-related ST-segment changes.

Same-day exercise electrocardiography and ambulatory electrocardiographic (Holter) monitoring were performed on 167 patients, all of whom had suffered myocardial infarctions over the past 12 years. A significant correlation (P less than 0,0001) was found when comparing exercise testing for ischaemic ST-segment changes and the number of complexity of ventricular arrhythmias found on Holter monitoring. Two different methods of arrhythmia classification were used and the results were similar. The value of simultaneous Holter monitoring and exercise electrocardiography to detect 'late' exercise-related ventricular arrhythmias was not found to be sufficient to warrant their widespread simultaneous use.

Adult↗

Lack of correlation between the clinical assessment of cardiovascular status and exercise electrocardiography.

One hundred and seventy-one patients who had had a myocardial infarction were evaluated at the Institute for Aviation Medicine, Pretoria. Patients were graded according to the New York City Heart Association classification of cardiac functional capacity and then subjected to exercise electrocardiography. Only 20% of the 74 patients whose exercise electrocardiograms revealed ischaemic heart disease felt that their cardiovascular function was limiting their daily activity. This lack of correlation between the two forms of assessment was highly significant (P less than 0,0001). It is therefore concluded that clinical evaluation of an individual with known ischaemic heart disease may be misleading.

Adult↗

Postexercise blood pressure as a predictor of hypertension.

A study on 721 healthy male aircrew assessed whether the blood pressure response to exercise could be used to predict the development of hypertension. A positive blood pressure response to exercise, recorded 30 s after the completion of exercise, was defined as a systolic blood pressure of 200 torr or more (systolic test) or a raised diastolic blood pressure (diastolic test). While 236 (32.7%) became hypertensive with a blood pressure greater than 149/90 torr, 17% of these had shown a positive systolic response and 17% a positive diastolic response. The other 485 individuals (67.3%) remained normotensive throughout the mean follow-up period of 68 months (range 12-170 months). Of this group, 88% never manifested a positive systolic or diastolic response to exercise. Although 5% of the normotensive subjects manifested a positive systolic response to exercise, and 12% manifested a positive diastolic response to exercise, a longer period of follow-up may reduce this figure. It is concluded that exercise related blood pressure is a useful test in predicting the development of essential hypertension.

Adult↗

Atenolol as primary therapy in previously untreated hypertensives and as an adjuvant to other therapy. A South African Multicentre Study.

A series of 50 previously untreated hypertensives (group A) were treated with atenolol 100 mg daily and matching placebo in a double-blind cross-over study. A series of 60 hypertensives who were poorly controlled on non-beta-adrenergic receptor blocking drugs, as evidenced by a diastolic blood pressure of between 100 and 120 mmHg inclusive (group B), were treated in the same manner as group A except that they continued to take their previous non-beta-adrenergic receptor blocking drugs throughout the trial. The large majority of patients in both groups (95% and 72%) experienced a fall in blood pressure to satisfactory levels with no significant additional side-effects when compared with placebo treatment.

Adjuvants, Pharmaceutic↗