PubMed Health⌕ Search

Biomedical subjects

A J Dalby

Publications and source records attributed to A J Dalby.

9 recordsLinked to original sources
PubMed1981

Effect of glucose-insulin-potassium infusions on epicardial ECG changes and on myocardial metabolic changes after coronary artery ligation in dogs.

The effect of glucose-insulin-potassium infusion (GIK) on developing myocardial infarction in dogs was evaluated, commencing infusion 30 min after coronary artery ligation (CAL). The parameters studied were: early (60 min after CAL) and late (6 and one half h after CAL) epicardial ST segment elevation, the change in Q, R, and S waves and certain myocardial metabolic determinations (glycogen, sodium, potassium, dry-wet weight ratio, adenosine triphosphate, creatine phosphate, inorganic phosphate, and lactate). 6 and one half h after coronary ligation Q wave amplitude was less, the R wave amplitude was greater and the metabolic profile in hte infarct zone was less deranged; metabolic improvement was also found in the nonischaemic zone. Sites in which early ST-segment elevation was less with GIK did not predict all the sites in which there was eventual lessened Q wave formation. R wave fall and disturbance of myocardial metabolism. This study supports others showing an effect of GIK in improving the features of developing experimental myocardial infarction. Following the rate of Q wave development in relation to the early ST segment elevation may be of value in assessing GIK effects provided that a qualitative rather than quantitative relationship between the two parameters is accepted.

Animals↗
PubMed1980

The clinical assessment and management of patients with prosthetic cardiac valves: A review of current practice at the Cardiac Clinic, Groote Schuur Hospital.

This review deals with the clinical assessment and management of patients with prosthetic cardiac valves. The types of prosthesis available are considered, with special reference to those which have been used frequently at Groot Schuur Hospital. The common complications encountered are described, as well as the clinical features of normally and abnormally functioning prostheses. The management of anticoagulant medication, pregnancy, infective endocarditis, systemic embolism and haemolysis in these patients is discussed. Particular emphasis is placed on the urgent referral to a cardiac department of patients with posthetic malfunction or conditions in which there is a potential for the development of malfunction.

Animals↗
PubMed1979

Acquired pulmonary stenosis.

A patient with acquired pulmonary stenosis due to lymphocytic lymphoma is presented. Three further patients with acquired pulmonary stenosis have been seen in our department in the past 15 years. A review of published cases reveals that there are more causes of this condition than have previously been enumerated.

Adult↗
PubMed1977

Acute of fulminating myelofibrosis.

Patients who run a fulminating course in association with histologically proven myelofibrosis are distinctly unusual, since the natural history of this entity is characteristically one of slow progression. Because of its rarity and proteam manifestations, acute myelofibrosis may easily go unrecognized. We report 2 such patients. In one, rapid clinical deterioration was dominated by spreading skin lesions, and in the other by refractory intravascular haemolysis. There was no splenomegaly in the first patient, and it was minimal in the second. Although it is seen in frequently, it should be emphasized that myelofibrosis may arise de novo as an acute illness in which the usual degree of splenomegaly is absent.

Acute Disease↗