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Biomedical subjects

A J Flach

Publications and source records attributed to A J Flach.

50 records · Page 3Linked to original sources
PubMed1983

Amiodarone-induced lens opacities.

Amiodarone hydrochloride is a benzofurane derivative used for cardiac abnormalities. Its use is commonly associated with an asymptomatic keratopathy. Although lipid deposits have been observed with the electron microscope in the lens epithelium of one patient with a history of amiodarone therapy, lens opacities have not been reported in patients using this drug. Visually inconsequential, anterior subcapsular lens opacities in seven of 14 patients using moderate to high doses of amiodarone who were examined at the Veterans Administration Hospital in San Francisco are reviewed.

Adult↗
PubMed1983

Post-ganglionic chemical sympathectomy of the cat nictitating membrane following systemic epinephrine: degeneration of nerve terminals followed by regeneration.

The present study was designed to provide further evidence that high doses of systemically administered epinephrine can result in a post-ganglionic chemical sympathectomy and to look for evidence of regeneration of nerve terminals. Three days following the systemic administration of a high dose of epinephrine a prolapse of the cat nictitating membrane was observed. Examination of the inferior smooth muscle associated with the membrane revealed ultrastructural evidence of nerve terminal destruction which was associated with a marked depletion of endogenous norepinephrine as measured with a catecholamine radioenzyme assay. Three weeks following treatment, appearance of nerve terminals and endogenous norepinephrine levels in the contralateral nictitating membrane were indistinguishable from untreated controls. High doses of epinephrine appear to result in nerve terminal degeneration, followed by regeneration, similar to that reported following 6-hydroxydopamine.

Animals↗
PubMed1983

Ptosis in the rat following topically administered 2% epinephrine.

Commercially available 2% epinephrine instilled twice daily in one eye of 15 rats resulted in ptosis after 4 weeks treatment. The ptosis was indistinguishable from that observed following topical treatment with 6-hydroxydopamine 20% and surgical sympathectomy. Ptosis in both epinephrine- and 6-hydroxydopamine-treated rats was associated with a statistically significant depletion of ocular norepinephrine, as determined by a sensitive catecholamine radio enzyme assay. Ultrastructural evidence of nerve terminal degeneration was present near the smooth muscle of Müller within the eyelid of rats treated with epinephrine. This study provides further evidence epinephrine administration can result in chemical sympathectomy as has been described following 6-hydroxydopamine.

Administration, Topical↗
PubMed1980

Supersensitivity to topical epinephrine after long-term epinephrine therapy.

Two patients received long-term topical therapy with epinephrine in one eye. One week after cessation of therapy, the treated eye in each patient showed more sensitivity to epinephrine than the untreated eye. The possibility of denervation supersensitivity and some clinical implications of this observation are discussed.

Administration, Topical↗
PubMedDate not supplied

Cyclo-oxygenase inhibitors in ophthalmology.

Cyclo-oxygenase inhibitors, which are formulated as ophthalmic eyedrop preparations, have recently become commercially available for use by ophthalmologists in the United States to inhibit intraoperative miosis during cataract surgery and to prevent postoperative inflammation. In addition, they are available worldwide as ocular antiinflammatory drugs and are used in the prevention and treatment of pseudophakic and aphakic cystoid macular edema. Understanding the rationale behind the use of these agents requires an understanding of the pathophysiology of the cyclo-oxygenase inhibitors. In this review recent advances in laboratory and clinical science are emphasized. The role of COIs during and following surgery is examined.

Animals↗