Gastrointestinal symptoms.
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Biomedical subjects
Publications and source records attributed to A J Greenwald.
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The suitability of a radiopharmaceutical for measuring gastric emptying time of solid meal is described. The gastric emptying T1/2 value of solid meal in normal individuals has been established. Both animal and human experiments indicate 99mTc-DTPA to be an ideal nonabsorbable marker for determing gastric emptying rate and for other gastrointestinal studies as well. Studies are now underway to determine gastric emptying time in patients with gastrectomy and gastrojejunostomy, vagotomy, pyloroplasty, etc.
An elderly man with long-standing pulmonary emphysema was seen with recent onset of steatorrhea and ascites. He had very low levels of serum alpha1-antitrypsin, hepatic cirrhosis, and intestinal mucosal atrophy. We believe this this combination of findings did not occur by chance.
A comparative study between modified conventional saline load test and the more recently introduced radioisotopic method was run in 8 normal volunteers. Each subject underwent at least three studies by each of the two methods: (1) aspiration method of Goldstein and Boyle incorporating our modification, and (2) an isotopic method employing a gamma camera with a computer. A liquid meal of isotonic saline was used with or without (997) MTc-DTPA. The results indicated that the gastric emptying T 1/2 (8.8 +/- 3.5 min) obtained by saline load test was shorter than that obtained by isotopic method (12 +/- 3 min). This discrepancy was most likely due to inherent error (incomplete aspiration of the gastric fluid) in the former method giving rise to a false faster emptying time. Moreover, the variations in T 1/2 value in the same individual was much more in the aspiration method than it was in the isotopic method.
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