Inhibition of gustatory rhinorrhoea by intranasal ipratropium bromide.
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Adult↗
Biomedical subjects
A J Harrison
Publications and source records attributed to A J Harrison.
Ipratropium bromide delivered orally by metered dose inhaler does not decrease salivary flow in normal subjects.
A randomised placebo-controlled cross-over group study was conducted to ascertain the occurrence and duration of xerostomia induced by 240 micrograms (high dose) and 120 micrograms (low dose) of ipratropium bromide (IPB) delivered by metered dose inhaler (MDI) into the mouth in normal subjects. Salivary output was higher with both doses of IPB than with placebo though the differences were not statistically significant. IPB was less palatable than placebo as indicated on visual analogue scale (VAS) and the taste of the drug may have caused a reflex increase in salivary output from the major salivary glands which would have masked any possible local effect of the drug on the smaller submucosal glands of the mouth. IPB delivered into the oral cavity by MDI is therefore not a suitable treatment for hypersalivation.
Administration, Inhalation↗
Attempts to immunize monkeys against Plasmodium knowlesi by using heat-stable, serum-soluble antigens.
Thirty-six Macaca mulatta monkeys were immunized with different concentrations and regimens of heat-stable, serum-soluble (S-) antigens of Plasmodium knowlesi prior to challenge with the homologous parasite via sporozoite inoculation. Fewer deaths and reduced maximum parasitemias occurred in those animals inoculated with 10 to 40 mg of S-antigen compared to nonimmunized monkeys or those receiving only Freund's adjuvant. Protection was incomplete, however, suggesting that atibodies to S-antigens may have a limited role in protection of hosts to malarial infection.
Animals↗
Lead and tin in canned foods: results of the UK survey 1983-1987.
Concentrations of tin and lead in canned foods have been monitored since 1983 to determine the effects of recent changes in can-making technology. In the sample studied the proportion of foods contained in non-soldered as opposed to soldered cans has risen consistently during the survey and now accounts for 83% of all samples (excluding sardines). Foods contained in non-soldered cans have lower lead concentrations than those contained in soldered cans and this changeover is likely to result in a decrease in dietary lead intakes in the UK.
Food Contamination↗