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Biomedical subjects

A J Knell

Publications and source records attributed to A J Knell.

At least 19 recordsLinked to original sources
PubMed1978

Serum methionine: its rapid determination by continuous-flow colorimetry.

A rapid automated method for the determination of serum methionine is presented for use with the Technicon AutoAnalyzer system. It is based on the decolorisation of halide platinates by organic sulphides, including methionine. The 5--95% reference range from 249 sera from hospital patients (excluding those with liver and renal diseases and diabetes) was 20--60 mumol/l, mean 35 mumol/l. The S.D. of the method for 40 duplicate samples was 2.2 mumol/l. Recoveries ranged from 101--105%. This measurement facilitates the clinical evaluation of liver disease, especially acute liver failure, kidney disease and diabetes mellitus.

Autoanalysis↗
PubMed1977

Acute liver failure.

Explore the source record for details and available documents.

Hepatic Encephalopathy↗
PubMed1976

Dialysis procedures in acute liver coma.

9 haemodialyses against fluids designed to reduce plasma abnormality were used in four patients with acute liver failure in an attempt to maintain consciousness and buy time for liver regeneration. Dialysis had little effect in two patients. In the third patient spontaneous movements and response to commands were seen during the second dialysis. Arousal occurred during both dialyses in the fourth patient who eventually recovered.

Acute Disease↗
PubMed1976

The 3H-labelling of bilirubin.

A simple method has been developed for the preparation of 3H-labelled bilirubin IX-alpha from bilirubin dimethyl ester. The label is located in the propionic acid side chains, and there is no isomerization of the bilirubin during the preparation.

Bilirubin↗
PubMed1974

Dopamine and serotonin metabolism in hepatic encephalopathy.

Patients with stupor or coma from fulminant hepatic failure were found to have high cerebrospinal fluid concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA), metabolites of dopamine and serotonin respectively. Excessive amounts of their precursors-phenylalanine and tyrosine and free tryptophan-were found in the patients' plasma. Methionine, which participates in dopamine degradation, was also much increased. Similar disturbances were found in patients suffering an acute exacerbation of chronic encephalopathy. These abnormalities would be consistent with other evidence of an increased turnover of serotonin and possibly dopamine in the brain during hepatic encephalopathy.

Acetaminophen↗
PubMed1973

Metal complexes of bilirubin in aprotic solvents.

Bilirubin reacts with zinc acetate, cadmium acetate or cobaltous acetate in dry dipolar aprotic solvents to form highly coloured complexes. The complex formed in NN-dimethylformamide can be isolated as a solid with bilirubin:zinc:acetate:NN-dimethylformamide molar proportions of 1:3:2:2. Water will decompose these complexes, with the regeneration of bilirubin.

Acetates↗
PubMed1973

The synthesis of esters of bilirubin.

1-Alkyl-3-p-tolytriazenes were used to synthesize the methyl, ethyl, isopropyl and benzyl esters of bilirubin. Treatment of a chloroform solution of bilirubin with the triazene at room temperature gave high yields of the corresponding esters. These were identified by n.m.r. and mass spectroscopy together with elemental analysis. N.m.r. studies also suggest that bilirubin dimethyl ester is in the lactam rather than the lactim form.

1-Propanol↗