Biomedical subjects
A J Kroll
Publications and source records attributed to A J Kroll.
Transpupillary thermotherapy of occult subfoveal choroidal neovascularization in patients with age-related macular degeneration.
OBJECTIVE: To evaluate the efficacy of transpupillary thermotherapy for the treatment of occult subfoveal choroidal neovascularization (CNV) in patients with age-related macular degeneration. DESIGN: A retrospective, noncomparative case series. PARTICIPANTS: Sixteen eyes of 15 consecutive patients who presented with occult subfoveal choroidal neovascularization secondary to age-related macular degeneration. INTERVENTION: After informed consent was obtained, 16 eyes of 15 patients were treated with transpupillary thermotherapy. All patients underwent pretreatment fluorescein angiography and were deemed untreatable by the Macular Photocoagulation Study standard. Transpupillary thermotherapy was delivered using a diode laser at 810 nm. A variable spot size of 1.2 mm, 2.0 mm, or 3.0 mm was used depending on the size of CNV. The diode laser was delivered through a contact lens, and treatment was initiated in one spot for 60 seconds' duration at a power range between 360 and 1000 mW. The end point was an area of no visible color change to a light-gray appearance. MAIN OUTCOME MEASURES: In all eyes, outcome was assessed by Snellen chart visual acuity and clinical examination. In 10 of 16 eyes, preoperative and postoperative fluorescein angiography and optical coherence tomography were available. In the remaining 6 of 16 eyes, exudation was measured by postoperative clinical examination alone. RESULTS: Three eyes (19%) showed a two-or-more-line improvement in visual acuity over a period of 6 to 25 months. Mean follow-up was 13 months. Visual acuity remained stable (no change or one-line improvement) in nine treated eyes (56%). The remaining four eyes (25%) showed a decline (equal to one-line worsening or greater) in visual acuity. Fifteen eyes (94%) demonstrated decreased exudation on fluorescein angiography, optical coherence tomography, and/or clinical examination. CONCLUSIONS: Transpupillary thermotherapy shows no deleterious side effects in treating occult subfoveal choroidal neovascularization. A randomized, prospective study is necessary to evaluate treatment efficacy.
Surgical management of macular hole.
Explore the source record for details and available documents.
Acute retinal necrosis syndrome: findings, management, and differential diagnosis.
Explore the source record for details and available documents.
Experimental retinal detachment in the owl monkey. VII. Photoreceptor protein renewal in normal and detached retina.
Explore the source record for details and available documents.
Experimental retinal detachment in the owl monkey. 8. Photoreceptor protein renewal in early retinal reattachment.
Explore the source record for details and available documents.
Proliferation of Descemet's membrane.
Explore the source record for details and available documents.
Experimental retinal detachment in the owl monkey. V. Electron microscopy of the reattached retina.
Explore the source record for details and available documents.
Experimental retinal detachment and reattachment in the rhesus monkey. Electron microscopic comparison of rods and cones.
Explore the source record for details and available documents.
Secondary retinal detachment. Electron microscopy of retina and pigment epithelium.
Explore the source record for details and available documents.
Experimental retinal detachment and reattachment: II. Electron microscopy.
Explore the source record for details and available documents.
Experimental central retinal artery occlusion. An electrophysiological study.
Explore the source record for details and available documents.
Experimental central retinal artery occlusion.
Explore the source record for details and available documents.
Experimental retinal detachment in the owl monkey. 3. Electron microscopy of retina and pigment epithelium.
Explore the source record for details and available documents.
Fine-sturctural classification of orbital rhabdomyosarcoma.
Explore the source record for details and available documents.
Dysthyroid exophthalmos. Palliation by lateral orbital decompression.
Explore the source record for details and available documents.
Dysthyroid ocular myopathy. Anatomy, histology, and electron microscopy.
Explore the source record for details and available documents.
Vitreous hemorrhage complicating retinal astrocytic hamartoma.
Tuberous sclerosis classically presents a triad of mental deficiency, seizures and adenoma sebaceum. Among the ocular manifestations are astrocytic hamartomas in the retina. This paper describes the case of a 24-year-old man with tuberous sclerosis who had recurrent vitreous hemorrhage from a large epipapillary astrocytic hamartoma in the left eye. Pars plana vitrectomy cleared the vitreous and bimanual bipolar coagulation of tumor bleeding points was done. Fragments of the friable tumor were obtained with the vitrectomy instrument and were prepared for tissue culture, histology, and electron microscopy. Although pars plana vitrectomy offers certain advantages over other methods of biopsy, it does present a danger of extraocular seeding of malignant cells; therefore, it is not recommended in cases with probable intraocular malignancy.