THE STRESS RESPONSIVE INDOLE SUBSTANCE IN SLEEP DEPRIVATION.
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Biomedical subjects
Publications and source records attributed to A J MANDELL.
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A group of cases and review of the literature is presented documenting the interesting clinical phenomenon of an inverse temporal relationship between asthmatic symptoms and clinical psychiatric symptoms in some patients. It is suggested that physicians treating asthmatic patients should be prepared to handle potential psychiatric complications that may be concomitants of the successful medical management of patients with asthma.
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Paper chromatograms on extracts from serial 6-hr urine samples from humans of both sexes on indole-controlled diets revealed either the appearance of or marked increment in "spot 32" (1) after ACTH gel injections. This corresponds in time and duration with the rise in 17-hydroxycorticoid excretion. 5-Hydroxyindoleacetic acid and 28 other urinary indoles failed to show this rise predictably.
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Patients with Parkinson's syndrome whose major symptoms are akinesis, rigidity, inertia, depression, irritability and failure of adaptation rather than tremor appear to benefit in a global way from therapy with imipramine. Patients without much over-all functional impairment do not show this improvement. The hypothesis is offered that motivation to move and ability to move are perhaps neurologically as well as psychologically related functions.
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