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Biomedical subjects

A J Raper

Publications and source records attributed to A J Raper.

At least 19 recordsLinked to original sources
PubMed1978

Role of tissue hypoxia in local regulation of cerebral microcirculation.

The mechanism of action of hypoxia on cerebral blood vessels and its role in the regulation of the cerebral circulation were investigated in anesthetized cats. Arterial hypoxia produced marked cerebral arteriolar vasodilation, which was partially reversed by perfusing the space under the cranial window with artificial cerebrospinal fluid (CSF) containing 6-94% oxygen. More marked increase in the local supply of oxygen, via perfusion of the space under the cranial window with fluorocarbon FC-80 equilibrated with 100% oxygen, completely eliminated the vasodilation induced by arterial hypoxia. Fluorocarbon equilibrated with 100% N2 had no effect on the vasodilation. The vasodilation associated with hypotension was completely reversed by perfusion with fluorocarbon equilibrated with 100% oxygen and was unaffected by perfusion with fluorocarbon or CSF equilibrated with gas not containing oxygen. The vasodilation associated with Metrazole-induced seizures was partially reversed by perfusion with fluorocarbon containing oxygen. The results show that hypoxia dilated cerebral blood vessels entirely via a local mechanism, that hypoxia is the dominant mechanism involved in the vasodilation associated with hypotension, and that it is, at least partially, responsible for the vasodilation associated with seizures.

Animals↗
PubMed1977

Pheochromocytoma of the urinary bladder: a broad clinical spectrum.

A case of pheochromocytoma of the urinary bladder is reported, and 35 perviously reported cases are analyzed. This interesting entity can present with symptoms of catecholamine excess and severe hypertensive spells (often micturition-induced) or as asymptomatic hematuria without hypertension. The present case represents the severest end of the clinical spectrum, with advancing acute retinopathy and visual loss, very high blood pressure and greatly increased catecholamine excretion. Several special precautions were utilized during diagnostic studies and surgery. On the whole, prognosis is excellent in nonmalignant cases properly handled, and the location of the tumor provides opportunity for early case finding and complete cure.

Adult↗
PubMed1977

Paraganglioma of urinary bladder wall.

A classic case of pheochromocytoma of the urinary bladder is presented. The history of headaches and palpitations during micturition is the result of sudden release of catecholamines into the general circulation. The diagnosis using selective arteriography as well as the medical and surgical management are described.

Adult↗
PubMed1976

Hypertension screening among dental patients.

Between January 1974 and March 1975, blood pressures were taken on all 2,222 dental patients admitted for treatment at the Virginia Commonwealth University, Medical College of Virginia School of Dentistry. According to the criteria of an elevated diastolic blood pressure (above 95 mm Hg) at three successive readings not less than five days apart, 131 patients were referred to physicians as suspected hypertensives. One hundred and thirteen patients were deemed hypertensive by their physician. A positive family history of hypertension was noted for 54% of the 113 undetected hypertensives. Of the 113 hypertensives, 6% visited their dentist yearly but did not visit their physician during the same time. On this basis we conclude that about 6% of dental patients can be expected to be referred to physicians as a result of high blood pressure screening in a dentist's office.

Adult↗
PubMed1976

A dental school hypertension screening program.

This paper has described a hypertension screening program at the Medical College of Virginia School of Dentistry. The program, which has been in operation for over two years, incorporates referral to a physician and a system of repeated follow-ups. The results indicate that the program has been successful in that 134 of a total of 141 patients with suspected hypertension have been successfully referred.

Blood Pressure↗