Biomedical subjects
Publications and source records attributed to A J Sear.
A case initially thought to be ameloblastoma of the mandible which showed rapid local destruction and was demonstrated to have three pulmonary metastases post mortem 18 months after the first symptoms in the mandible. The diagnosis is now considered to be ameloblastic carcinoma. The difficulties in histological diagnosis and varying classifications of malignant odontogenic tumours is noted.
A case of malignant calcifying epithelial odontogenic tumour is reported in a 75-year-old man. Evidence of local tissue invasion and lymph-node metastasis is presented. Immunoperoxidase studies of the neoplastic cells and tumour amyloid were negative for a variety of antigens, including the epithelial markers CEA and keratin. The histological and clinical findings are discussed.
The influenza A/Ann Arbor/6/60 (H2N2) cold-adapted (ca) virus was evaluated as a donor of attenuating genes to new variants of influenza A virus. This ca donor virus was mated with the A/Alaska/6/77 (H3N2) wild-type virus, and three A/Alaska/6/77 (H3N2) ca recombinant viruses were produced. The parental origin of the genes in the three ca recombinants had been determined previously (2), and their virulence for adult seronegative volunteers was assessed in the present study to identify the genes present in the ca donor virus that confer attenuation. Each of the recombinants received the hemagglutinin and neuraminidase genes from the A/Alaska/6/77 (H3N2) wild-type parent. One ca recombinant (CR-29) received all six transferable genes from the ca parent and was found to be satisfactorily attenuated in the volunteers. The two other ca recombinants received five of the six transferable genes with a wild-type gene at the M or NS locus. The pattern of infection in humans with these latter two ca recombinants was similar to the CR-29 ca recombinant. These findings demonstrate that inheritance of a gene in ca recombinants at the M or NS locus segregates independently of attenuation and suggest that the M and NS genes present in the ca donor virus are not the major determinants of attenuation conferred by this virus.
A method of intra-nasal splinting has been outlined which revives principles and improves on methods established particularly well by two French Stomatologists at the beginning of this century. It uses a simple splint, carefully chosen from a range of sizes, that requires precise insertion, and has proved to have several advantages over more commonly employed techniques.
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