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Biomedical subjects

A J Stone

Publications and source records attributed to A J Stone.

10 recordsLinked to original sources
PubMed2001

A pilot study of rhuIL-11 treatment of refractory ITP.

The objective of this research was to determine whether rhuIL-11 is an effective treatment in patients with refractory immune thrombocytopenic purpura (ITP). Platelet production is decreased in certain cases of refractory ITP. IL-11 stimulates megakaryocytopoiesis in vitro and was licensed for its clinical effects to ameliorate chemotherapy-induced thrombocytopenia. A pilot study was initiated, intending to enroll 12 patients with ITP. These patients were to receive rhuIL-11 (Neumega) at a dose of 50 microg/kg subcutaneously daily for 21 consecutive days and be observed afterward for 21 additional days. CBC with platelets were obtained twice weekly with visits and physical examinations weekly. The study was terminated after 7 patients were enrolled because of toxicity and lack of efficacy. All 7 patients had had ITP for >9 years and had failed splenectomy, intravenous gammaglobulin, corticosteroids, and a variety of other treatments. The patients at entry all had platelet counts <20,000/microl; 5 of 7 had counts <10,000/microl. The maximal median increase for any day of the study was 6,000/microl. No patient achieved a count of 30,000/microl, and only 3 patients achieved (once each) a platelet count >20,000/microl. Substantial toxicity was seen. The nadir hemoglobin decrease was a mean of 2 g/dl. rhuIL-11 was not effective at increasing the platelet count in any of these patients with refractory ITP. Toxicity was substantial. The lack of platelet response to rhuIL-11 in this study does not exclude the possibility of better effects at other doses and/or in less refractory patients.

Adolescent↗
PubMed1989

Designing interventions to prevent HIV-1 infection by promoting use of condoms and spermicides among intravenous drug abusers and their sexual partners.

This paper summarizes the results of a 2-day workshop to identify the most effective educational strategies to promote use of condoms and spermicides for preventing heterosexual transmission of HIV-1 virus from intravenous drug abusers (IVDA) to their steady, nonintravenous drug abusing (NIVDA) sexual partners. Representatives from health departments, drug abuse treatment centers, academic institutions, service organizations, and the community discussed issues relating to population characteristics, educational strategies and recruitment techniques. A consensus document that identifies the most effective recruitment and intervention strategies was developed. Recruitment issues include locations, recruitment targets, anticipated difficulties, and ethical considerations. The majority of workshop participants agreed that an intervention should target the couple (both IVDA and NIVDA). Intervention concerns encompass obtaining trust, maintaining participation, and identifying guidelines to maximize program impact.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Detection of benign cardiac fibroma on thallium-201 imaging in an adult.

A rare case of benign cardiac fibroma causing a focal defect on Tl-201 imaging in an adult patient is presented. The abnormalities on the Tl-201 scan are correlated with other studies performed on the same patient. The usefulness of the Tl-201 myocardial perfusion scan as an early, noninvasive test in cardiac workup is stressed.

Adult↗
PubMed1986

Correlates of accurate knowledge of cancer.

Knowledge acquisition, although a prerequisite of preventive behavior, has been a neglected area of research. Mass communication research shows that audience characteristics explain most of the variation in knowledge acquistion. Since cancer information is mainly disseminated via the media, we hypothesized that the same audience characteristics would be related to accuracy of cancer knowledge. Bivariate and multivariate associations between the hypothesized variables and a cancer knowledge score were tested using a three-stage random sample of Los Angeles County (N = 931). Smoking status, education, degree of cancer worry, health improvement behavior, ethnicity, age, household size, and frequency of health worry were related to knowledge accuracy. An examination of the underlying dimensions of cancer knowledge revealed three beliefs about cancer: smoking causes cancer; cancer can be cured; and the environment does not cause cancer. Smoking status, ethnicity, health improvement behavior, and worry about cancer and health were associated with the belief that smoking causes cancer. The independent variables in this study were not significantly related to the other two beliefs. These results conform with the general predictions of mass communication research. We conclude that targeting of cancer information and particular uses of media could raise the general level of cancer knowledge.

Adolescent↗
PubMed1983

Is hostility linked with affiliation among males and with achievement among females? A critique of Pollak and Gilligan.

This investigation attempted to replicate and to clarify methodologically an investigation by Pollak and Gilligan (1982). Those investigators reported sex differences in violence imagery to Thematic Apperception Test (TAT) pictures depicting affiliation and achievement situations. Pollak and Gilligan concluded that men perceive danger in situations of affiliation whereas women perceive danger in situations of achievement. It was demonstrated in the present study that Pollak and Gilligan incorrectly classified TAT cards into motivational categories, which may have resulted in incorrect inferences. In addition, their findings could not be replicated when using four different systems for classifying TAT cards into motivational categories. Other potential sources of error in their research, including a restrictive scoring scheme for hostility, unusual instructions, and failure to control for sex role in the TAT pictures, did not influence the pattern of results.

Achievement↗