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Biomedical subjects

A J Stubbs

Publications and source records attributed to A J Stubbs.

11 recordsLinked to original sources
PubMed1989

Cerebral-evoked response from stimulation of dorsal nerve in impotent men.

Cerebral-evoked responses from 128 uncategorized, impotent men were compared with responses from 17 healthy age-height matched controls, after stimulation of two penile sites, and one tibial nerve at the ankle. Our goal has been to establish a simple screening test to identify neurogenic impotence in patients with normal superficial sensation. High-frequency stimulation at 5.7 c/s and minimal repetitions (300) per trial, allowed thirty to forty minute sessions in alert subjects. With these methods, the amplitudes of cerebral responses at N2 were most informative. All volunteers had measurable amplitude while 11.9 percent of patients did not. An additional 4.5 percent of patients had amplitude suppression of 2 SD compared with the control mean, suggesting that as many as 16.4 percent of such patients may have neural damage. Prolonged latencies alone were rare and not included in this total. Ninety-two of these 128 patients had Doppler flow studies, and only 2 showed both Doppler and electrical abnormalities. This suggests that neurogenic problems may often be independent of vascular disease. This evoked-response screen of the entire genitocerebral neuraxis offers a safe method of identifying a portion of those patients with neurogenic impotence.

Diabetes Mellitus↗
PubMed1979

Office uroflowmetry using a maximum flow rate purge meter.

The use of a purge size rotameter for the determination of maximum urinary flow rates represents an inexpensive and non-invasive method to detect obstructive or neurogenic lower urinary tract abnormalities. We have used the device to identify successfully selected patients with such abnormalities.

Adult↗
PubMed1978

Anatrophic nephrolithotomy in the solitary kidney.

A retrospective analysis was conducted on 30 patients who had undergone anatrophic nephrolithotomy for staghorn calculus disease in a solitary kidney. No statistically significant difference (p greater than 0.1) was found between the average preoperative and postoperative renal function values. Of 27 patients who were infected preoperatively 19 were rendered free of further urinary tract infection and 24 of 30 patients (80 per cent) had no further recurrence of renal calculi. Because of the predictable morbidity and mortality associated with the non-operative management of staghorn calculus disease these patients are managed best by the complete surgical removal of all calculi and intensive antimicrobial therapy.

Adult↗
PubMed1978

Protein electrophoretic patterns of canine prostatic fluid. Effect of hormonal manipulation.

The effects of castration and estrogen administration on prostatic fluid proteins were compared in two groups of dogs. Prostatic fistulae were created in 10 animals and prostatic fluid secretions stimulated by electroejaculation. After a stabilization period, five animals were administered polyestradiol phosphate and the remaining five were castrated. After 3 months estrogen administration was discontinued and depo-testosterone was administered to the castrate animals. Fluids were collected at weekly intervals throughout the study and prostatic fluid proteins separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis. No difference between animal receiving estrogen and castrated animals was noted and administration of testosterone to castrate animals reestablished a normal protein pattern.

Animals↗
PubMed1977

Struvite staghorn calculi in crossed fused ectopia.

Two patients with a struvite staghorn calculus in crossed fused renal ectopia are described. The susceptibility of these patients to urinary tract infection is discussed as is the anomalous extrarenal arterial vasculature to the ectopic and non-ectopic kidneys. Both patients were treated successfully with anatrophic nephrolithotomy and each has remained free of recurrent calculous disease to date.

Adult↗
PubMed1977

Intrarenal nephrolithotomy and reconstruction of the solitary kidney.

There were 30 patients with solitary kidneys containing staghorn claculi who have been subjected to nephrolithotomy with extensive plastic revision of strictured calices using local renal hypothermia. These patients have been followed for 8 months to 16 years and all have had a recent in-hospital evaluation of renal function and recurrent stone formation. No surgical mortality occurred (death within 3 months of operation). Seven patients have died postoperatively, only 1 of whom had associated progressive deterioration of renal function as a contributory cause of death. It is concluded that surgical removal of calculi from a solitary kidney is a relatively safe procedure that results in significant improvement in the patient's well being. The degree of improvement is of such a nature that it may be equated to "cure of the disease" in 63 per cent of the patients.

Adolescent↗