Biomedical subjects
Publications and source records attributed to A J Sytkowski.
Clusters of acetylcholine receptors were formed in the absence of neurons during the development of cultured chick-embryo skeletal muscle cells. The average concentration of receptors in clusters was estimated to be 9000 per mum(2). At other regions of the cell, receptor concentration was 900 per mum(2). The possibility that receptor clusters may participate in synapse formation is suggested.
[(125)I]Monoiodo- and [(125)I]diiodo-alpha-bungarotoxin were synthesized and shown to bind specifically to the acetylcholine receptor of cultured embryonic chick- and rat-muscle cells. The pharmacologic properties of the receptor of cultured embryonic chick muscle resembled those of the nicotinic acetylcholine receptor of adult vertebrate muscle. Autoradiography of muscle cells labeled with toxin showed that acetylcholine receptors were distributed over the entire cell surface. In addition, discrete areas with a high receptor concentration were found.
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