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A J Wiley

Publications and source records attributed to A J Wiley.

3 recordsLinked to original sources

Images of adolescence in English literature: the middle ages to the modern period.

It is argued that modern images of adolescence are also reflected in English literary tradition. Thus, relevant works of the major authors, Chaucer, More, Locke, Shakespeare, Bayly, Milton, Prior, Wordsworth, Coleridge, Hazlitt, and Dickens, are analyzed for their imagery of youth and adolescence. It is concluded that, with minor exceptions, the way that youth are depicted in these works remains remarkably stable over time. The main theme of adolescence throughout these works is that it is a time of turbulence, excess, and passion. This is in consonance with the modern-day view of adolescence as a time of storm and stress.

Adolescent↗

Assessment of binding indices and physiological responsiveness of the 5-HT2 receptor on human platelets.

This is the first report of parallel studies of binding indices and physiological responsiveness of the "Serotonin-two" (5-HT2) receptor on the human platelet membrane. Binding indices were measured by a microassay employing [125I]ILSD as radioligand and ketanserin to define specific binding. A single receptor population was found, characterized by a KD of 1.69 +/- 0.45 nM and Bmax of 14.5 +/- 6.0 pmol/g protein in healthy subjects. Functional responsiveness of the platelet 5-HT2 receptor complex was assessed by measurement of the extent to which serotonin (10uM) augmented platelet aggregation induced by threshold concentrations of adenosine diphosphate (ADP). A statistically significant positive correlation was found between the number of platelet 5-HT2 receptor sites (Bmax) and the magnitude of the serotonin-amplified aggregation response (r = .70, n = 38, p less than 0.001). Assessment of binding indices and physiological responsiveness of the platelet 5-HT2 receptor complex should facilitate study of age, hormonal, disease, and drug effects on 5-HT2 receptor function in human subjects.

Adenosine Diphosphate↗

Bacteria in Coal.

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Journal Article↗