[NCI policy and veterinary medical practice automatization].
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Computer Communication Networks↗
Biomedical subjects
A J van Toor
Publications and source records attributed to A J van Toor.
[SLE (systemic lupus erythematosus)-related clinical features in dogs].
Three dogs presented with lameness and/or vague clinical signs. The results of immunological tests were suggestive of a SLE-related syndrome. ANA (antinuclear antibodies) titres were very high, 1:40960 in one of the dogs, and antibodies against single-stranded DNA were detected. Complement levels were very low in two dogs. Antibodies against histones were detected in both the serum and the synovial fluid of one dog. In another dog there was evidence of high concentrations of PCNA antibodies, which in humans are specific for SLE. It is concluded that the three dogs showed signs of a syndrome possibly related to SLE. The description of the clinical signs and of the laboratory diagnostics serve as a clinical demonstration to draw colleagues' attention to this nosologically interesting clinical syndrome and to the need to request specific immunological tests when this syndrome is suspected.
Animals↗
Hyperadrenocorticism in four cats.
This paper describes four cats with hyperadrenocorticism. Cat 1 showed polydipsia and polyphagia. Diabetes mellitus was initially diagnosed. As the animal appeared to be insulin resistant, pituitary and adrenocortical function tests were performed and the diagnosis of hyperadrenocorticism was made. Resistance to the high-dose dexamethasone suppression test was noticed in this cat. Pathological examination revealed a pituitary chromophobe adenoma. Cat 2 presented with diabetes mellitus, which was treated with insulin. The animal had a pendulous abdomen and its coat was in a poor condition. The low-dose dexamethasone suppression test demonstrated hyperadrenocorticism. Necropsy findings of pituitary tumour and hyperplasia of the adrenal cortex confirmed the diagnosis. Cat 3 showed clinical abnormalities indicative of hyperadrenocorticism, for instance, muscle weakness, alopecia, multiple abscesses. The diagnosis of hyperadrenocorticism was confirmed by the results of the lowe-dose dexamethasone suppression test. Pathological examination revealed an adrenocortical carcinoma. Cat 4 presented with polydipsia. The cause of this symptom was not found initially. One and a half years later additional symptoms, such as nephritis and polyphagia developed. Hyperadrenocorticism was diagnosed because of a palpable mass cranial to the left kidney. The diagnosis was confirmed by the results of the lowe-dose dexamethasone suppression test and the necropsy findings.
Animals↗
Experimental induction of fasting hypoglycaemia and fatty liver syndrome in three Yorkshire terrier pups.
Eight hours fasting in Yorkshire terrier pups resulted in marked variation of blood glucose, showing both hypo- en hyperglycaemia. Prolonged fasting in three Yorkshire terrier pups resulted in hypoglycaemia with concomitant ketosis and steatosis of the liver. The hypoglycaemia was associated with decreasing insulin and increasing glucagon and cortisol levels. This is in contrast to fasting adult dogs, which maintain glucohomeostasis and show only slightly decreased insulin levels, normal glucagon levels and a moderate increase of plasma ketone bodies. The reaction to an eight hour fasting period in the Yorkshire terrier pups is thought to be related to inadequate gluconeogenesis and diminished insulin production and/or release. The different reaction to prolonged fasting, compared to adult dogs and pups of larger breeds, seems related to inadequate gluconeogenesis and results in hypoglycaemia, a ketogenic hormonal setting and steatosis of the liver. Frequent feeding of a high-energy, protein-rich diet to both mother and pups may prevent toy-breed pups from developing hypoglycaemia and may help them to overcome periods with a decreased intake of energy.
Animals↗
Aluminium intoxication in a dog.
A two-year-old male Barsoi dog was presented after a two-week period of muscle twitching and convulsions during exercise, which worsened to a state of tetraparesis and coma. Removal of a gastric foreign body, containing aluminium, resolved the presenting signs. Parallel with this clinical recovery the elevated serum levels of aluminium decreased to values of two normal control dogs, suggesting that the neurological signs were due to A1 intoxication.
Aluminum↗
[Idiopathic fatty liver syndrome in cats].
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Animals↗
Quantitative analysis of radioaerosol inhalation and perfusion scintigraphy in dogs.
A method was developed for the analysis of 99mTc MAA perfusion and 99mTc phytate colloid aerosol inhalation distribution patterns. Scintigraphic images were compared, based on the activity of corresponding picture elements (pixels). The possible mismatching in a pixel between both distributions was expressed in terms of a regional mismatching (common to a whole region) and an additional intraregional mismatching at the individual pixel level. Parameters characterizing the degree of regional and intraregional mismatching were introduced. The method was applied to 16 anesthetized healthy dogs in which a cranial-to-caudal gradient in regional mismatching was found.
Aerosols↗