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Biomedical subjects

A J vd Heijden

Publications and source records attributed to A J vd Heijden.

5 recordsLinked to original sources
PubMed1988

Renal functional impairment in preterm neonates related to intrauterine indomethacin exposure.

Renal function was measured during the first 4 postnatal days in 9 preterm neonates (gestational age 26.2 to 31 wk) exposed to indomethacin during the last 2 days of pregnancy (group I). The data were compared to those obtained from nine control neonates (gestational age 28 to 34.5 wk) (group II). Five of the nine neonates in group I were markedly edematous at birth, none of group II were edematous. Urine production in group I was low (32.2 +/- 16.8 ml/kg.day on day 1 increasing to 68.6 +/- 21.4 ml/kg.day on day 4) and differed significantly from group II [75.2 +/- 26.8 ml/kg.day on day 1 increasing to 84.8 +/- 20.9 ml/kg.day on day 4 (p less than 0.001)]. Fluid intake was adapted to urine production when necessary. A continuous inulin infusion was started directly after admission and continued for 5 days. Renal function was evaluated for 3 consecutive days after at least 48 h of insulin infusion. The values of the inulin clearance, serum creatinine, urine osmolarity, osmolar clearance, and free water clearance were stable in both groups during the study period. Inulin clearance was lower in group I than in group II (p less than 0.001), whereas serum creatinine was higher in group I than in group II (p less than 0.0001). Urine osmolarity was higher in group I (p less than 0.01), whereas osmolar clearance and free water clearance were lower in group I (p less than 0.02, respectively, p less than 0.01). There was no difference in fractional sodium excretion between the groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Female↗
PubMed1986

Effect of hypercapnic acidosis on renal function in the newborn rabbit.

Anaesthetized mechanically ventilated newborn rabbits were exposed to different degrees of hypercapnia. One hour of normocapnia was used as a control period. Renal function studies demonstrated an increase in renal vascular resistance with a concomitant decrease in effective renal plasma flow in all hypercapnic animals, combined with a less pronounced decrease in glomerular filtration rate. Filtration fraction rose significantly. A decrease in systemic blood pressure was only observed when the PaCO2 exceeded 100 mm Hg combined with an arterial pH below or equal to 7.10. We conclude that normoxemic hypercapnia in the newborn rabbit leads to an increase in renal vascular resistance and suggest that the renal vasoconstriction predominates at the level of the efferent arteriole.

Acidosis↗
PubMed1985

Acute tubular dysfunction in infants with obstructive uropathy.

Eleven patients are described with severe hyponatraemia, hyperkalaemia and metabolic acidosis associated with a urinary tract infection and obstructive uropathy. This clinical entity resembles adrenocortical disorders. Urine culture investigation in combination with abdominal ultrasound examination will reveal urinary tract obstruction. Differential diagnosis, pathogenesis and treatment are discussed. In most patients correction of the metabolic disturbance can be achieved with antibiotic treatment, occasionally in combination with surgical therapy. Some degree of polyuria will generally persist.

Acidosis↗
PubMed1984

Oxalosis in infancy.

Two cases of oxalosis in infancy are reported, the diagnosis and therapy are discussed and the world literature reviewed. Oxalosis in infancy is a rare condition, probably most frequently caused by a fulminant form of the autosomal recessive type I primary hyperoxaluria. It presents symptoms of renal failure in early infancy. This is progressive and usually causes death within three months after the onset of symptoms. The diagnosis can be suspected after simple procedures (abdominal roentgenogram, urinary tract ultrasonography) and confirmed by urine/plasma analysis and kidney biopsy/bone marrow aspiration. An exact diagnosis is important since it has consequences concerning genetic counseling and treatment. Dialysis and transplantation may be useful in secondary oxalosis, but until now they are hard to justify in infantile primary oxalosis. In primary hyperoxaluria (type I), pyridoxine therapy gives hopeful results before the onset of oxalosis, but unsatisfactory results after the onset of oxalosis.

Consanguinity↗